Protein Domain : IPR016040

Type:  Domain Name:  NAD(P)-binding domain
Description:  This entry represents NAD- and NADP-binding domains with a core Rossmann-type fold, which consists of 3-layers alpha/beta/alpha, where the six beta strands are parallel in the order 321456. Many different enzymes contain an NAD/NADP-binding domain, including:C-terminal domain of alcohol dehydrogenases []Tyrosine-dependent oxidoreductases (also known as short-chain dehydrogenases) []N-terminal domain of glyceraldehyde-3-phosphate dehydrogenase []NAD-binding domain of formate/glycerate dehydrogenases []N-terminal domain of sirohaem synthase []N-terminal domain of lactate dehydrogenase []N-terminal domain of 6-phosphogluconate dehydrogenase (the beta-sheet is extended to 8 strands) []C-terminal domain of amino acid dehydrogenases (an extra N-terminal helix displaces the C-terminal helix []NAD-binding domain of certain potassium channels []C-terminal domain of the transcriptional repressor Rex []Ornithine cyclodeaminase []CoA-binding N-terminal domain of the alpha chain of succinyl-CoA synthetase [] Short Name:  NAD(P)-bd_dom
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24 Child Features

DB identifier Type Name
IPR001732 Domain UDP-glucose/GDP-mannose dehydrogenase, N-terminal
IPR006367 Domain Sirohaem synthase, N-terminal
IPR000594 Domain THIF-type NAD/FAD binding fold
IPR013968 Domain Polyketide synthase, ketoreductase domain
IPR006096 Domain Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal
IPR000846 Domain Dihydrodipicolinate reductase, N-terminal
IPR005097 Domain Saccharopine dehydrogenase, NADP binding domain
IPR002225 Domain 3-beta hydroxysteroid dehydrogenase/isomerase
IPR008030 Domain NmrA-like domain
IPR001236 Domain Lactate/malate dehydrogenase, N-terminal
IPR028939 Domain Pyrroline-5-carboxylate reductase, catalytic, N-terminal
IPR006176 Domain 3-hydroxyacyl-CoA dehydrogenase, NAD binding
IPR012302 Domain Malic enzyme, NAD-binding
IPR011128 Domain Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal
IPR006140 Domain D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
IPR006115 Domain 6-phosphogluconate dehydrogenase, NADP-binding
IPR006151 Domain Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
IPR020631 Domain Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
IPR022674 Domain Glucose-6-phosphate dehydrogenase, NAD-binding
IPR003781 Domain CoA-binding
IPR013120 Domain Male sterility, NAD-binding
IPR013332 Domain Ketopantoate reductase, N-terminal domain
IPR003869 Domain Polysaccharide biosynthesis protein, CapD-like domain
IPR019665 Domain Putative oxidoreductase/dehydrogenase, Rossmann-like domain

18 Contains

DB identifier Type Name
IPR013021 Domain Myo-inositol-1-phosphate synthase, GAPDH-like
IPR019572 Domain Ubiquitin-activating enzyme, catalytic cysteine domain
IPR000683 Domain Oxidoreductase, N-terminal
IPR006037 Domain Regulator of K+ conductance, C-terminal
IPR003148 Domain Regulator of K+ conductance, N-terminal
IPR013549 Domain Domain of unknown function DUF1731
IPR013131 Domain Mannitol dehydrogenase, N-terminal
IPR002204 Conserved_site 3-hydroxyisobutyrate dehydrogenase-related, conserved site
IPR020830 Active_site Glyceraldehyde 3-phosphate dehydrogenase, active site
IPR018074 Active_site Ubiquitin-activating enzyme, E1, active site
IPR015884 Conserved_site Malic enzyme, conserved site
IPR020904 Conserved_site Short-chain dehydrogenase/reductase, conserved site
IPR002364 Conserved_site Quinone oxidoreductase/zeta-crystallin, conserved site
IPR020082 Conserved_site S-adenosyl-L-homocysteine hydrolase, conserved site
IPR019796 Active_site Glucose-6-phosphate dehydrogenase, active site
IPR008143 Conserved_site Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2
IPR006181 Conserved_site D-amino acid oxidase, conserved site
IPR020867 Conserved_site Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site

1 Cross References

Identifier
G3DSA:3.40.50.720

92 Found Ins

DB identifier Type Name
IPR012070 Family Arogenate dehydrogenase 2
IPR017476 Family UDP-glucose/GDP-mannose dehydrogenase
IPR011859 Family Dihydrodipicolinate reductase, plant-type
IPR000304 Family Pyrroline-5-carboxylate reductase
IPR011274 Family Malate dehydrogenase, NAD-dependent, cytosolic
IPR002198 Family Short-chain dehydrogenase/reductase SDR
IPR003560 Family 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR002347 Family Glucose/ribitol dehydrogenase
IPR005762 Family UDP-N-acetylmuramoylalanine-D-glutamate ligase
IPR002424 Family Alcohol dehydrogenase, insect-type
IPR002587 Family Myo-inositol-1-phosphate synthase
IPR008089 Family Nucleotide sugar epimerase
IPR006424 Family Glyceraldehyde-3-phosphate dehydrogenase, type I
IPR020831 Family Glyceraldehyde/Erythrose phosphate dehydrogenase family
IPR010945 Family Malate dehydrogenase, type 2
IPR011273 Family Malate dehydrogenase, NADP-dependent, plants
IPR010097 Family Malate dehydrogenase, type 1
IPR001557 Family L-lactate/malate dehydrogenase
IPR001891 Family Malic oxidoreductase
IPR018075 Family Ubiquitin-activating enzyme, E1
IPR005886 Family UDP-glucose 4-epimerase GalE
IPR011304 Family L-lactate dehydrogenase
IPR005913 Family dTDP-4-dehydrorhamnose reductase family
IPR011284 Family 3-oxoacyl-(acyl-carrier-protein) reductase
IPR003929 Family Potassium channel, calcium-activated, BK, alpha subunit
IPR010099 Family Epimerase family protein SDR39U1
IPR006368 Family GDP-mannose 4,6-dehydratase
IPR000672 Family Tetrahydrofolate dehydrogenase/cyclohydrolase
IPR001282 Family Glucose-6-phosphate dehydrogenase
IPR010420 Family CASTOR/POLLUX/SYM8 ion channels

0 GO Annotation

0 Ontology Annotations

0 Parent Features

131595 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
448626 D8T8Q0 PAC:15407396 Selaginella moellendorffii 404  
171031 D8RFM4 PAC:15405807 Selaginella moellendorffii 548  
410568 D8RF58 PAC:15406450 Selaginella moellendorffii 156  
410874 D8RG52 PAC:15408766 Selaginella moellendorffii 360  
410869 D8RG47 PAC:15408748 Selaginella moellendorffii 324  
410942 D8RGD0 PAC:15409510 Selaginella moellendorffii 132  
440944 D8RFM3 PAC:15408731 Selaginella moellendorffii 408  
440990 D8RFW0 PAC:15408848 Selaginella moellendorffii 373  
92349 D8RF44 PAC:15417673 Selaginella moellendorffii 284  
92506 D8RFY0 PAC:15419134 Selaginella moellendorffii 332  
231517 D8RHI6 PAC:15417457 Selaginella moellendorffii 332  
93869 D8RGW6 PAC:15402113 Selaginella moellendorffii 247  
93705 D8RGK2 PAC:15423436 Selaginella moellendorffii 282  
93941 D8RHJ3 PAC:15402754 Selaginella moellendorffii 126  
272294 D8TB19 PAC:15402354 Selaginella moellendorffii 411  
229723 PAC:15412891 Selaginella moellendorffii 473  
136252 D8TBI6 PAC:15415643 Selaginella moellendorffii 143  
39244 D8RHV0 PAC:15416454 Selaginella moellendorffii 84  
231648 D8RHV5 PAC:15418308 Selaginella moellendorffii 321  
411497 D8RI47 PAC:15408677 Selaginella moellendorffii 952  
431536 D8TCZ4 PAC:15401388 Selaginella moellendorffii 193  
412037 D8RJU7 PAC:15408381 Selaginella moellendorffii 101  
231782 D8RK93 PAC:15419163 Selaginella moellendorffii 344  
412332 D8RKT6 PAC:15410801 Selaginella moellendorffii 104  
172432 D8RLM7 PAC:15411880 Selaginella moellendorffii 341  
172571 D8RL65 PAC:15412718 Selaginella moellendorffii 309  
412487 D8RLM5 PAC:15411666 Selaginella moellendorffii 275  
412432 D8RLH1 PAC:15411552 Selaginella moellendorffii 390  
412430 D8RLG9 PAC:15411550 Selaginella moellendorffii 308  
96850 D8RL61 PAC:15410919 Selaginella moellendorffii 290  

12 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14595395
            11276087
            9174344
            11301020
            9917402
            10448043
            8591026
            15449945
            15518536
            15642260
            8114093
            17222187