| Type: | Family | Name: | Malate dehydrogenase, type 2 |
| Description: | Malate dehydrogenases catalyse the interconversion of malate and oxaloacetate using dinucleotide cofactors []. The enzymes in this entry are found in archaea, bacteria and eukaryotes and fall into two distinct groups. The first group are cytoplamsic, NAD-dependent enzymes which participate in the citric acid cycle (). The second group are found in plant chloroplasts, use NADP as cofactor, and participate in the C4 cycle ().Structural studies indicate that these enzymes are homodimers with very sinmilar overall topology, though the chloroplast enzymes also have N- and C-terminal extensions, and all contain the classical Rossman fold for NAD(P)H binding [, , , ]. Substrate specificity is determined by a mobile loop at the active site which uses charge balancing to discriminate between the correct substrates (malate and oxaloacetate) and other potential oxo/hydroxyacid substrates the enzyme may encounter within the cell []. | Short Name: | Malate_DH_type2 |
| DB identifier | Type | Name |
|---|---|---|
| IPR016040 | Domain | NAD(P)-binding domain |
| IPR015955 | Domain | Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
| IPR022383 | Domain | Lactate/malate dehydrogenase, C-terminal |
| IPR001236 | Domain | Lactate/malate dehydrogenase, N-terminal |
| IPR001252 | Active_site | Malate dehydrogenase, active site |
| GO Term | Gene Name |
|---|---|
| GO:0016615 | IPR010945 |
| GO:0006108 | IPR010945 |
| GO:0055114 | IPR010945 |
