| Type: | Active_site | Name: | Malate dehydrogenase, active site |
| Description: | Malate dehydrogenase () (MDH) [] catalyzes the interconversionof malate to oxaloacetate utilizing the NAD/NADH cofactor system. The enzyme participates in the citric acid cycle and exists in all aerobics organisms.While prokaryotic organisms contains a single form of MDH, in eukaryotic cells there are two isozymes: one which is located in the mitochondrial matrix andthe other in the cytoplasm. Fungi and plants also harbor a glyoxysomal form which functions in the glyoxylate pathway. In plants chloroplast there is anadditional NADP-dependent form of MDH () which is essential for both the universal C3 photosynthesis (Calvin) cycle and the more specialisedC4 cycle.The pattern for this enzyme includes two residues involved in the catalytic mechanism []: an aspartic acid whichis involved in a proton relay mechanism, and an arginine which binds the substrate. | Short Name: | Malate_DH_AS |
| DB identifier | Type | Name |
|---|---|---|
| IPR011274 | Family | Malate dehydrogenase, NAD-dependent, cytosolic |
| IPR015955 | Domain | Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
| IPR022383 | Domain | Lactate/malate dehydrogenase, C-terminal |
| IPR010945 | Family | Malate dehydrogenase, type 2 |
| IPR011273 | Family | Malate dehydrogenase, NADP-dependent, plants |
| IPR010097 | Family | Malate dehydrogenase, type 1 |
| GO Term | Gene Name |
|---|---|
| GO:0016615 | IPR001252 |
| GO:0006108 | IPR001252 |
| GO:0055114 | IPR001252 |
