Protein Domain : IPR022383

Type:  Domain Name:  Lactate/malate dehydrogenase, C-terminal
Description:  L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis []. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate []. The enzyme participates in the citric acid cycle.This entry represents the C-terminal, and is thought to be an is an unusual alpha+beta fold. Short Name:  Lactate/malate_DH_C
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0 Child Features

2 Contains

DB identifier Type Name
IPR001252 Active_site Malate dehydrogenase, active site
IPR018177 Active_site L-lactate dehydrogenase, active site

1 Cross References

Identifier
PF02866

8 Found Ins

DB identifier Type Name
IPR011274 Family Malate dehydrogenase, NAD-dependent, cytosolic
IPR010945 Family Malate dehydrogenase, type 2
IPR011273 Family Malate dehydrogenase, NADP-dependent, plants
IPR010097 Family Malate dehydrogenase, type 1
IPR001557 Family L-lactate/malate dehydrogenase
IPR011304 Family L-lactate dehydrogenase
IPR011275 Family Malate dehydrogenase, type 3
IPR011272 Family Lactate dehydrogenase, protist

2 GO Annotations

GO Term Gene Name
GO:0016616 IPR022383
GO:0055114 IPR022383

2 Ontology Annotations

GO Term Gene Name
GO:0016616 IPR022383
GO:0055114 IPR022383

1 Parent Features

DB identifier Type Name
IPR015955 Domain Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
92401 D8RFP2 PAC:15418338 Selaginella moellendorffii 340  
405919 D8R035 PAC:15416888 Selaginella moellendorffii 300  
421109 D8SE66 PAC:15413480 Selaginella moellendorffii 217  
133026 D8T6I0 PAC:15405148 Selaginella moellendorffii 351  
89860 D8RBW3 PAC:15412504 Selaginella moellendorffii 341  
270710 D8RBD7 PAC:15422450 Selaginella moellendorffii 447  
271992 D8SY75 PAC:15404726 Selaginella moellendorffii 331  
90290 D8RCK2 PAC:15411215 Selaginella moellendorffii 358  
270780 PAC:15422646 Selaginella moellendorffii 352  
evm.TU.contig_33425.1 PAC:16430269 Carica papaya 93  
evm.model.supercontig_129.41 PAC:16407544 Carica papaya 356  
evm.model.supercontig_131.66 PAC:16408063 Carica papaya 339  
evm.model.supercontig_20.65 PAC:16413092 Carica papaya 329  
evm.model.supercontig_29.108 PAC:16416131 Carica papaya 350  
evm.model.supercontig_423.5 PAC:16419878 Carica papaya 411  
evm.model.supercontig_44.59 PAC:16420199 Carica papaya 354  
evm.model.supercontig_706.3 PAC:16425408 Carica papaya 339  
29900.m001590 B9S977 PAC:16812468 Ricinus communis 343  
30099.m001624 B9S7S1 PAC:16817645 Ricinus communis 356  
30138.m004069 B9RLY1 PAC:16819434 Ricinus communis 412  
30150.m000471 B9SE47 PAC:16820647 Ricinus communis 345  
30174.m008801 B9RD45 PAC:16822446 Ricinus communis 332  
28872.m000247 B9T307 PAC:16801899 Ricinus communis 433  
29636.m000769 B9SIT4 PAC:16804369 Ricinus communis 350  
29636.m000768 B9SIT3 PAC:16804368 Ricinus communis 350  
29200.m000165 B9T5E4 PAC:16802447 Ricinus communis 332  
28830.m000233 B9T172 PAC:16801764 Ricinus communis 332  
Cucsa.383610.1 A0A0A0LII5 PAC:16982415 Cucumis sativus 333  
Cucsa.383610.4 A0A0A0LII5 PAC:16982418 Cucumis sativus 333  
Cucsa.383610.5 PAC:16982419 Cucumis sativus 327  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11276087
            8117664