Protein Domain : IPR000846

Type:  Domain Name:  Dihydrodipicolinate reductase, N-terminal
Description:  Dihydrodipicolinate reductase catalyzes the second step in the biosynthesis of diaminopimelic acid and lysine, the NAD or NADP-dependent reduction of 2,3-dihydrodipicolinate into 2,3,4,5-tetrahydrodipicolinate [, , ].In Escherichia coliand Mycobacterium tuberculosis, dihydrodipicolinate reductase has equal specificity for NADH and NADPH, however in Thermotoga maritimathere it has a greater affinity for NADPH []. In addition, the enzyme is inhibited by high concentrations of its substrate, which consequently acts as a feedback control on the lysine biosynthesis pathway. In T. maritima, the enzyme also lacks N-terminal and C-terminal loops which are present in enzyme of the former two organisms.This entry represents the N-terminal domain of dihydrodipicolinate reductase which binds the dinucleotide NAD(P)H. Short Name:  DapB_N
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0 Child Features

0 Contains

1 Cross References

Identifier
PF01113

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0008839 IPR000846
GO:0009089 IPR000846
GO:0055114 IPR000846

3 Ontology Annotations

GO Term Gene Name
GO:0008839 IPR000846
GO:0009089 IPR000846
GO:0055114 IPR000846

1 Parent Features

DB identifier Type Name
IPR016040 Domain NAD(P)-binding domain

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
168311 D8R6G2 PAC:15421275 Selaginella moellendorffii 288  
75294 D8QN51 PAC:15411418 Selaginella moellendorffii 313  
evm.model.supercontig_107.7 PAC:16405376 Carica papaya 183  
evm.model.supercontig_182.24 PAC:16411575 Carica papaya 386  
30147.m014305 B9R9G4 PAC:16820316 Ricinus communis 300  
28266.m000195 B9T529 PAC:16800458 Ricinus communis 354  
Cucsa.007160.1 PAC:16951205 Cucumis sativus 362  
Cucsa.250960.3 PAC:16971731 Cucumis sativus 287  
Cucsa.250960.4 PAC:16971732 Cucumis sativus 240  
Cucsa.250960.1 PAC:16971729 Cucumis sativus 300  
Cucsa.250960.2 PAC:16971730 Cucumis sativus 292  
orange1.1g024671m A0A067D771 PAC:18134868 Citrus sinensis 264  
orange1.1g028115m A0A067DFH4 PAC:18134869 Citrus sinensis 213  
orange1.1g022250m A0A067F9D6 PAC:18101158 Citrus sinensis 300  
orange1.1g022057m A0A067EY71 PAC:18101157 Citrus sinensis 303  
orange1.1g027650m A0A067F1V8 PAC:18101160 Citrus sinensis 220  
orange1.1g031341m A0A067EYB0 PAC:18101163 Citrus sinensis 161  
orange1.1g031216m A0A067F9E1 PAC:18101162 Citrus sinensis 163  
orange1.1g025154m A0A067FA56 PAC:18101159 Citrus sinensis 257  
AT5G52100.1 Q9FJ82 PAC:19670377 Arabidopsis thaliana 298  
AT3G59890.1 Q8LB01 PAC:19663782 Arabidopsis thaliana 349  
AT3G59890.2 Q8LB01 PAC:19663783 Arabidopsis thaliana 343  
AT2G44040.1 O80574 PAC:19642463 Arabidopsis thaliana 347  
Thhalv10006083m V4L1E9 PAC:20190629 Eutrema salsugineum 338  
Thhalv10014460m V4LLH4 PAC:20203792 Eutrema salsugineum 255  
Thhalv10001534m V4KMD1 PAC:20188868 Eutrema salsugineum 341  
Ciclev10020914m V4TPC8 PAC:20810644 Citrus clementina 349  
Ciclev10005510m V4S434 PAC:20791224 Citrus clementina 303  
Ciclev10005683m V4SDM1 PAC:20791225 Citrus clementina 257  
Lus10041701 PAC:23146716 Linum usitatissimum 337  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7893645
            8873595
            9398235
            18250105