Protein Domain : IPR006115

Type:  Domain Name:  6-phosphogluconate dehydrogenase, NADP-binding
Description:  6-Phosphogluconate dehydrogenase () (6PGD) is an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. This reaction is a component of the hexose mono-phosphate shunt and pentose phosphate pathways (PPP) [, ]. Prokaryotic and eukaryotic 6PGD are proteins of about 470 amino acids whose sequence are highly conserved []. The protein is a homodimer in which the monomers act independently []: each contains a large, mainly alpha-helical domain and a smaller beta-alpha-beta domain, containing a mixed parallel and anti-parallel 6-stranded beta sheet []. NADP is bound in a cleft in the small domain, the substrate binding in an adjacent pocket []. This family represents the NADP binding domain of 6-phosphogluconate dehydrogenase which adopts a Rossman fold. The C-terminal domain is described in . Short Name:  6PGDH_NADP-bd
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0 Child Features

1 Contains

DB identifier Type Name
IPR002204 Conserved_site 3-hydroxyisobutyrate dehydrogenase-related, conserved site

1 Cross References

Identifier
PF03446

5 Found Ins

DB identifier Type Name
IPR015815 Family 3-hydroxyisobutyrate dehydrogenase-related
IPR006183 Family 6-phosphogluconate dehydrogenase
IPR006113 Family 6-phosphogluconate dehydrogenase, decarboxylating
IPR011548 Family 3-hydroxyisobutyrate dehydrogenase
IPR006398 Family 2-hydroxy-3-oxopropionate reductase

2 GO Annotations

GO Term Gene Name
GO:0004616 IPR006115
GO:0055114 IPR006115

2 Ontology Annotations

GO Term Gene Name
GO:0004616 IPR006115
GO:0055114 IPR006115

1 Parent Features

DB identifier Type Name
IPR016040 Domain NAD(P)-binding domain

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
440990 D8RFW0 PAC:15408848 Selaginella moellendorffii 373  
98399 D8RNJ9 PAC:15413034 Selaginella moellendorffii 491  
168478 D8R545 PAC:15422173 Selaginella moellendorffii 487  
440731 D8RDZ9 PAC:15407114 Selaginella moellendorffii 1683  
evm.model.supercontig_122.20 PAC:16407067 Carica papaya 495  
evm.model.supercontig_25.52 PAC:16414847 Carica papaya 259  
evm.model.supercontig_3.389 PAC:16416689 Carica papaya 907  
evm.model.supercontig_53.7 PAC:16422296 Carica papaya 406  
evm.model.supercontig_586.2 PAC:16423093 Carica papaya 315  
evm.model.supercontig_70.14 PAC:16425296 Carica papaya 484  
evm.model.supercontig_8.10 PAC:16426375 Carica papaya 290  
evm.model.supercontig_80.84 PAC:16426812 Carica papaya 350  
29706.m001350 B9S5X5 PAC:16806362 Ricinus communis 348  
29832.m000313 B9SXT4 PAC:16810221 Ricinus communis 488  
29841.m002898 B9RVA7 PAC:16810611 Ricinus communis 495  
30074.m001363 B9S702 PAC:16816926 Ricinus communis 380  
30146.m003574 B9RQL0 PAC:16819694 Ricinus communis 314  
30146.m003575 B9RQL1 PAC:16819695 Ricinus communis 313  
30174.m008928 B9RDH0 PAC:16822571 Ricinus communis 333  
30190.m010775 B9RCL8 PAC:16823143 Ricinus communis 495  
30190.m011089 B9RBY8 PAC:16823449 Ricinus communis 322  
31113.m000025 B9TIV0 PAC:16824819 Ricinus communis 213  
35039.m000020 B9THJ7 PAC:16826461 Ricinus communis 427  
60395.m000025 B9TM46 PAC:16829352 Ricinus communis 202  
29668.m000313 B9SQH3 PAC:16805203 Ricinus communis 296  
Cucsa.111650.2 PAC:16960068 Cucumis sativus 1340  
Cucsa.111650.3 PAC:16960069 Cucumis sativus 1180  
Cucsa.111650.4 PAC:16960070 Cucumis sativus 992  
Cucsa.111650.1 PAC:16960067 Cucumis sativus 1372  
Cucsa.032520.1 PAC:16952462 Cucumis sativus 296  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1659648
            6641716
            2113917