Protein Domain : IPR015815

Type:  Family Name:  3-hydroxyisobutyrate dehydrogenase-related
Description:  This entry contains related reductases/dehydrogenases:3-hydroxyisobutyrate dehydrogenase (HIBADH) () catalyzes the NAD-dependent, reversible oxidation of 3-hydroxbutyrate to methylmalonate []. In eukaryotes, it is a homodimeric mitochondrial protein involved in valine catabolism. In Pseudomonas aeruginosa[] (gene mmsB), it is involved in the distal valine metabolic pathway.2-hydroxy-3-oxopropionate reductase () catalyses the NAP(P)H dependent reduction of 2-hydroxy-3-oxopropionate (tartronate semialdehyde) to D-glycerate. 2-(hydroxymethyl)glutarate dehydrogenase () catalyses the conversion of 2-formylglutarate to (S)-2-hydroxymethylglutarate [].Putative oxidoreductase GLYR1, also known as 3-hydroxyisobutyrate dehydrogenase-like protein or nuclear protein NP60, which regulates p38 MAP kinase activity []. Short Name:  HIBADH-related
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3 Child Features

DB identifier Type Name
IPR011548 Family 3-hydroxyisobutyrate dehydrogenase
IPR006398 Family 2-hydroxy-3-oxopropionate reductase
IPR030876 Family 3-sulfolactaldehyde reductase

3 Contains

DB identifier Type Name
IPR013328 Domain 6-phosphogluconate dehydrogenase, domain 2
IPR006115 Domain 6-phosphogluconate dehydrogenase, NADP-binding
IPR002204 Conserved_site 3-hydroxyisobutyrate dehydrogenase-related, conserved site

1 Cross References

Identifier
PIRSF000103

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0016491 IPR015815
GO:0055114 IPR015815

2 Ontology Annotations

GO Term Gene Name
GO:0016491 IPR015815
GO:0055114 IPR015815

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
426559 D8SWR6 PAC:15408849 Selaginella moellendorffii 316  
evm.model.supercontig_113.56 PAC:16406068 Carica papaya 310  
evm.model.supercontig_78.21 PAC:16426196 Carica papaya 319  
30071.m000444 B9STG2 PAC:16816709 Ricinus communis 308  
Cucsa.341100.1 A0A0A0LID2 PAC:16979179 Cucumis sativus 311  
Cucsa.049580.1 PAC:16954008 Cucumis sativus 282  
Cucsa.116660.1 PAC:16960601 Cucumis sativus 314  
Cucsa.116680.1 PAC:16960603 Cucumis sativus 310  
Cucsa.033110.1 PAC:16952527 Cucumis sativus 306  
Cucsa.167070.2 PAC:16966228 Cucumis sativus 334  
orange1.1g021213m A0A067G6M2 PAC:18114597 Citrus sinensis 316  
orange1.1g024066m A0A067GIL2 PAC:18114600 Citrus sinensis 273  
orange1.1g025140m PAC:18132939 Citrus sinensis 257  
AT4G20930.1 Q9SUC0 PAC:19646072 Arabidopsis thaliana 347  
AT4G29120.1 Q9SZE1 PAC:19644606 Arabidopsis thaliana 334  
AT1G71170.1 Q9C991 PAC:19651461 Arabidopsis thaliana 299  
AT1G71180.1 Q949M8 PAC:19656958 Arabidopsis thaliana 318  
Thhalv10025955m V4P6U4 PAC:20193700 Eutrema salsugineum 275  
Thhalv10011682m V4KLI0 PAC:20184191 Eutrema salsugineum 311  
Thhalv10018932m V4KE55 PAC:20192196 Eutrema salsugineum 301  
Ciclev10001773m V4SC06 PAC:20787049 Citrus clementina 335  
Ciclev10001947m V4SWD3 PAC:20785731 Citrus clementina 307  
Ciclev10016238m V4UD87 PAC:20816601 Citrus clementina 273  
Lus10037629 PAC:23167235 Linum usitatissimum 329  
Lus10038545 PAC:23158324 Linum usitatissimum 331  
Lus10001349 PAC:23162022 Linum usitatissimum 306  
Lus10023258 PAC:23180983 Linum usitatissimum 346  
Potri.001G211500.1 B9GEW0 PAC:27042714 Populus trichocarpa 307  
Potri.001G465600.3 PAC:27042688 Populus trichocarpa 267  
Potri.001G465600.2 A0A2K2CE58 PAC:27042687 Populus trichocarpa 273  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2647728
            1339433
            18680749
            16352664