| Type: | Conserved_site | Name: | 3-hydroxyisobutyrate dehydrogenase-related, conserved site |
| Description: | This entry identifies a conserved site in reductases/dehydrogenases.3-hydroxyisobutyrate dehydrogenase () catalyzes the NAD-dependent, reversible oxidation of 3-hydroxbutyrate to methylmalonate []. In eukaryotes, it is a homodimeric mitochondrial protein involved in valine catabolism. In Pseudomonas aeruginosa[] (gene mmsB), it is involved in the distal valine metabolic pathway.2-hydroxy-3-oxopropionate reductase () catalyses the NAP(P)H dependent reduction of 2-hydroxy-3-oxopropionate (tartronate semialdehyde) to D-glycerate. 6-phosphogluconate dehydrogenase () catalyzes the NADP-dependent decarboxylation of 6-phosphogluconate to D-ribulose 5-phosphate and CO2. | Short Name: | 3-OH-isobutyrate_DH-rel_CS |
| DB identifier | Type | Name |
|---|---|---|
| IPR015815 | Family | 3-hydroxyisobutyrate dehydrogenase-related |
| IPR016040 | Domain | NAD(P)-binding domain |
| IPR006115 | Domain | 6-phosphogluconate dehydrogenase, NADP-binding |
| IPR006183 | Family | 6-phosphogluconate dehydrogenase |
| IPR011548 | Family | 3-hydroxyisobutyrate dehydrogenase |
| IPR006398 | Family | 2-hydroxy-3-oxopropionate reductase |
