Protein Domain : IPR006367

Type:  Domain Name:  Sirohaem synthase, N-terminal
Description:  Bacterial sulphur metabolism depends on the iron-containing porphinoid sirohaem. CysG is a multi-functional enzyme with S-adenosyl-L-methionine (SAM)-dependent bismethyltransferase, dehydrogenase and ferrochelatase activities. CysG synthesizes sirohaem from uroporphyrinogen III via reactions which encompass two branchpoint intermediates in tetrapyrrole biosynthesis, diverting flux first from protoporphyrin IX biosynthesis and then from cobalamin (vitamin B12) biosynthesis. CysG is a dimer. Its dimerisation region is 74 residues long, and acts to hold the two structurally similar protomers held together asymmetrically through a number of salt-bridges across complementary residues within the dimerisation region []. CysG dimerisation produces a series of active sites, accounting for CysG's multi-functionality, catalysing four diverse reactions:Two SAM-dependent methylationsNAD+-dependent tetrapyrrole dehydrogenationMetal chelationThis group represent a subfamily of CysG N-terminal region-related sequences. All sequences in the seed alignment for this model are N-terminal regions of known or predicted sirohaem synthases. The C-terminal region of each is uroporphyrin-III C-methyltransferase (), which catalyses the first step committed to the biosynthesis of either sirohaem or cobalamin (vitamin B12) rather than protohaem (haem). Functionally these sequences complete the process of oxidation and iron insertion to yield sirohaem. Sirohaem is a cofactor for nitrite and sulphite reductases, so sirohaem synthase is CysG of cysteine biosynthesis in some organisms. Short Name:  Sirohaem_synthase_N
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0 Child Features

1 Contains

DB identifier Type Name
IPR019478 Domain Sirohaem synthase, dimerisation domain

2 Cross Referencess

Identifier
PF13241
TIGR01470

2 Found Ins

DB identifier Type Name
IPR012066 Family Uroporphyrin-III C-methyltransferase, yeast
IPR012409 Family Sirohaem synthase

4 GO Annotations

GO Term Gene Name
GO:0043115 IPR006367
GO:0006779 IPR006367
GO:0019354 IPR006367
GO:0055114 IPR006367

4 Ontology Annotations

GO Term Gene Name
GO:0043115 IPR006367
GO:0006779 IPR006367
GO:0019354 IPR006367
GO:0055114 IPR006367

1 Parent Features

DB identifier Type Name
IPR016040 Domain NAD(P)-binding domain

30 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
267064 D8R546 PAC:15408135 Selaginella moellendorffii 583  
37061 I0YVL9 PAC:27385759 Coccomyxa subellipsoidea C-169 345  
109401 C1EFF1 PAC:27402697 Micromonas sp RCC299 388  
6983 A4S2Z2 PAC:27413773 Ostreococcus lucimarinus 183  
Brdisv1pangenome1007577m.p PAC:33658692 Brachypodium distachyon Pangenome 220  
Brdisv1pangenome1006814m.p PAC:33656908 Brachypodium distachyon Pangenome 176  
Brdisv1pangenome1010311m.p PAC:33656122 Brachypodium distachyon Pangenome 197  
Brdisv1BdTR11A1042558m.p PAC:35687799 Brachypodium distachyon BdTR11a 181  
Brdisv1BdTR11A1042895m.p PAC:35691798 Brachypodium distachyon BdTR11a 155  
Brdisv1BdTR11A1043234m.p PAC:35690007 Brachypodium distachyon BdTR11a 316  
Brdisv1BdTR11A1041613m.p PAC:35696330 Brachypodium distachyon BdTR11a 176  
Bol036057 PAC:37357320 Brassica oleracea capitata 367  
Alyli.0118s0177.1.p PAC:39161987 Alyssum linifolium 365  
Alyli.0294s0039.1.p PAC:39139022 Alyssum linifolium 365  
Camar.1635s0005.1.p PAC:39605690 Cakile maritima 365  
Camar.0827s0022.1.p PAC:39630622 Cakile maritima 365  
Desop.0240s0527.1.p PAC:39659857 Descurainia sophioides 365  
Eruve.0226s0038.1.p PAC:39891218 Eruca vesicaria 365  
Eruve.2068s0026.1.p PAC:39955563 Eruca vesicaria 365  
Crahi.0330s0011.1.p PAC:39969885 Crambe hispanica 365  
Thupl.29336265s0001.1.p PAC:44990099 Thuja plicata 357  
Thupl.29358295s0001.5.p PAC:44948813 Thuja plicata 297  
Thupl.29358295s0001.1.p PAC:44948808 Thuja plicata 356  
Thupl.29380481s0008.5.p PAC:44996886 Thuja plicata 361  
Thupl.29380481s0008.1.p PAC:44996882 Thuja plicata 361  
Thupl.29380481s0008.2.p PAC:44996883 Thuja plicata 361  
Thupl.29380481s0008.3.p PAC:44996884 Thuja plicata 361  
Thupl.29380481s0008.4.p PAC:44996885 Thuja plicata 361  
Araha.11756s0127.1.p PAC:28856422 Arabidopsis halleri 432  
Araha.11756s0127.1.p PAC:28856422 Arabidopsis halleri 432  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14595395