Protein Domain : IPR020904

Type:  Conserved_site Name:  Short-chain dehydrogenase/reductase, conserved site
Description:  The short-chain dehydrogenases/reductases family (SDR) [, ] is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases. As the first member of this family to be characterised was Drosophila alcohol dehydrogenase, this family used to be called [, , ] 'insect-type', or 'short-chain' alcohol dehydrogenases. Most member of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases possess at least 2 domains [], the first binding the coenzyme, often NAD, and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis. Little sequence similarity has been found in the coenzyme binding domain although there is a large degree of structural similarity, and it has therefore been suggested that the structure of dehydrogenases has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains [].This entry contains a signature pattern for this family of proteins which covers one of the best conserved regions. It includes two perfectly conserved residues, a tyrosine and a lysine. The tyrosine residue participates in the catalytic mechanism. Short Name:  Sc_DH/Rdtase_CS
Paste the following link

0 Child Features

0 Contains

1 Cross References

Identifier
PS00061

19 Found Ins

DB identifier Type Name
IPR002198 Family Short-chain dehydrogenase/reductase SDR
IPR003560 Family 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR002347 Family Glucose/ribitol dehydrogenase
IPR016040 Domain NAD(P)-binding domain
IPR002424 Family Alcohol dehydrogenase, insect-type
IPR011284 Family 3-oxoacyl-(acyl-carrier-protein) reductase
IPR011286 Family 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase
IPR011294 Family 3-hydroxybutyrate dehydrogenase
IPR014007 Family Acetoin reductase
IPR015845 Family Agropine synthesis reductase
IPR002425 Family Alcohol dehydrogenase, Drosophila-type
IPR002426 Family Alcohol dehydrogenase, Ceratitis-type
IPR002427 Family Alcohol dehydrogenase-related
IPR011283 Family Acetoacetyl-CoA reductase
IPR011348 Family 17beta-dehydrogenase
IPR014058 Family Pteridine reductase
IPR017619 Family 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase
IPR017711 Family Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
IPR012115 Family Bifunctional ribulose 5-phosphate reductase/CDP-ribitol pyrophosphorylase

1 GO Annotation

GO Term Gene Name
GO:0016491 IPR020904

1 Ontology Annotations

GO Term Gene Name
GO:0016491 IPR020904

0 Parent Features

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7742302
            2707261
            1889416
            1740120
            6789320
            25526675