Protein Domain : IPR011348

Type:  Family Name:  17beta-dehydrogenase
Description:  This entry represents 17beta-hydroxysteroid dehydrogenases (17B-HSDs), a group of enzymes which catalyse the last step in the biosynthesis of all androgens and estrogens -the reversible NAD(P)-linked transfer of a hydride to and from the 17-position of steroid molecules []. A total of six isozymes have been identified which vary in substrate specificity, tissue specificity and preferred direction of the reaction.The most intensively studied enzyme in this entry is human estrogenic 17beta-hydroxysteroid dehydrogenase () which is responsible for the last step in the synthesis of all estrogens. As active estrogens stimulate the proliferation of breast cancer cells, this enzyme is a potential target for drugs to treat breast cancer []. It is a membrane-associated homodimer which posseses the Tyr-X-X-X-Lys motif typical of short-chain dehydrogenases and forms a typical Rossman fold []. Short Name:  17beta_DH
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0 Child Features

2 Contains

DB identifier Type Name
IPR016040 Domain NAD(P)-binding domain
IPR020904 Conserved_site Short-chain dehydrogenase/reductase, conserved site

1 Cross References

Identifier
PIRSF000095

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004303 IPR011348
GO:0006703 IPR011348
GO:0055114 IPR011348
GO:0005737 IPR011348

4 Ontology Annotations

GO Term Gene Name
GO:0004303 IPR011348
GO:0006703 IPR011348
GO:0055114 IPR011348
GO:0005737 IPR011348

1 Parent Features

DB identifier Type Name
IPR002347 Family Glucose/ribitol dehydrogenase

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7663947
            9927655
            8943783