| Type: | Domain | Name: | Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase |
| Description: | This entry represents a domain found in shikimate and quinate dehydrogenases, as well as glutamyl-tRNA reductases.Shikimate 5-dehydrogenase () catalyses the conversion of shikimate to 5-dehydroshikimate [, ]. This reaction is part of the shikimate pathway which is involved in the biosynthesis of aromatic amino acids []. Quinate 5-dehydrogenase catalyses the conversion of quinate to 5-dehydroquinate. This reaction is part of the quinate pathway where quinic acid is exploited as a source of carbon in prokaryotes and microbial eukaryotes. Both the shikimate and quinate pathways share two common pathway metabolites, 3-dehydroquinate and dehydroshikimate.Glutamyl-tRNA reductase () catalyzes the first step of tetrapyrrole biosynthesis in plants, archaea and most bacteria. The dimeric enzyme has an unusual V-shaped architecture where each monomer consists of three domains linked by a long 'spinal' alpha-helix. The central catalytic domain specifically recognises the glutamate moiety of the substrate []. | Short Name: | Shikm_DH/Glu-tRNA_Rdtase |
| DB identifier | Type | Name |
|---|---|---|
| IPR011342 | Family | Shikimate dehydrogenase |
| IPR000343 | Family | Tetrapyrrole biosynthesis, glutamyl-tRNA reductase |
| IPR021194 | Family | Uncharacterised protein family, dehydrogenase DR0790 type, predicted |
| IPR014215 | Family | Dipicolinic acid synthetase, subunit A |
| IPR010110 | Domain | Shikimate dehydrogenase, AroM-type |
