3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0003824 | IPR020867 |
| GO:0009396 | IPR020867 |
| GO:0055114 | IPR020867 |
| Type: | Conserved_site | Name: | Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site |
| Description: | Enzymes that participate in the transfer of one-carbon units require the coenzyme tetrahydrofolate (THF). Various reactions generate one-carbon derivatives of THF, which can be interconverted between differentoxidation states by methylene-THF dehydrogenase (), methenyl-THF cyclohydrolase () and formyl-THF synthetase () [, ]. The dehydrogenase and cyclohydrolaseactivities are expressed by a variety of multifunctional enzymes, including the tri-functional eukaryotic C1-tetrahydrofolate synthase []; a bifunctional eukaryotic mitochondrial protein; and thebifunctional Escherichia colifolD protein [, ]. Methylene-tetrahydrofolate dehydrogenase andmethenyltetrahydrofolate cyclo-hydrolase share an overlapping active site [], and as such areusually located together in proteins, acting in tandem on the carbon-nitrogen bonds of substrates other than peptide bonds.The sequence of the dehydrogenase/cyclohydrolase domain is highly conserved in all forms of the enzyme. This entry contains two conserved signature patterns; the first one is located in the N-terminal part of these enzymes and contains three acidic residues. The second pattern is a highly conserved sequence of 9 amino acids, which is located in the C-terminal section. | Short Name: | THF_DH/CycHdrlase_CS |
| GO Term | Gene Name |
|---|---|
| GO:0003824 | IPR020867 |
| GO:0009396 | IPR020867 |
| GO:0055114 | IPR020867 |
