Protein Domain : IPR020631

Type:  Domain Name:  Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
Description:  Enzymes that participate in the transfer of one-carbon units require the coenzyme tetrahydrofolate (THF). Various reactions generate one-carbon derivatives of THF, which can be interconverted between differentoxidation states by methylene-THF dehydrogenase (), methenyl-THF cyclohydrolase () and formyl-THF synthetase () [, ]. The dehydrogenase and cyclohydrolaseactivities are expressed by a variety of multifunctional enzymes, including the tri-functional eukaryotic C1-tetrahydrofolate synthase []; a bifunctional eukaryotic mitochondrial protein; and thebifunctional Escherichia colifolD protein [, ]. Methylene-tetrahydrofolate dehydrogenase andmethenyltetrahydrofolate cyclo-hydrolase share an overlapping active site [], and as such areusually located together in proteins, acting in tandem on the carbon-nitrogen bonds of substrates other than peptide bonds.This entry represents the NAD(P)-binding domain found in these enzymes. Short Name:  THF_DH/CycHdrlase_NAD-bd_dom
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0 Child Features

1 Contains

DB identifier Type Name
IPR020867 Conserved_site Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site

1 Cross References

Identifier
PF02882

2 Found Ins

DB identifier Type Name
IPR020630 Domain Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
IPR000672 Family Tetrahydrofolate dehydrogenase/cyclohydrolase

4 GO Annotations

GO Term Gene Name
GO:0003824 IPR020631
GO:0004488 IPR020631
GO:0009396 IPR020631
GO:0055114 IPR020631

4 Ontology Annotations

GO Term Gene Name
GO:0003824 IPR020631
GO:0004488 IPR020631
GO:0009396 IPR020631
GO:0055114 IPR020631

1 Parent Features

DB identifier Type Name
IPR016040 Domain NAD(P)-binding domain

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
404507 D8QVJ9 PAC:15410909 Selaginella moellendorffii 760  
99718 D8RRK1 PAC:15418797 Selaginella moellendorffii 294  
114081 D8SCR1 PAC:15416233 Selaginella moellendorffii 294  
126842 D8SWS1 PAC:15412993 Selaginella moellendorffii 302  
evm.model.supercontig_0.4 PAC:16403944 Carica papaya 256  
evm.model.supercontig_169.41 PAC:16410564 Carica papaya 241  
evm.model.supercontig_18.223 PAC:16411375 Carica papaya 367  
30073.m002203 B9S1W3 PAC:16816789 Ricinus communis 358  
30129.m000363 B9T0V4 PAC:16818648 Ricinus communis 299  
28806.m000146 B9T6E2 PAC:16801710 Ricinus communis 366  
Cucsa.097320.1 A0A0A0KWH1 PAC:16958173 Cucumis sativus 373  
Cucsa.247870.1 PAC:16971457 Cucumis sativus 332  
Cucsa.247870.2 PAC:16971458 Cucumis sativus 230  
orange1.1g024306m A0A067FA90 PAC:18106979 Citrus sinensis 269  
orange1.1g024282m A0A067FA90 PAC:18106980 Citrus sinensis 269  
orange1.1g027955m A0A067FLD1 PAC:18106982 Citrus sinensis 216  
orange1.1g027976m A0A067FLD1 PAC:18106981 Citrus sinensis 216  
orange1.1g017679m A0A067FM33 PAC:18106975 Citrus sinensis 368  
orange1.1g024083m A0A067FDQ1 PAC:18106976 Citrus sinensis 272  
orange1.1g024116m A0A067FDQ1 PAC:18106978 Citrus sinensis 272  
orange1.1g024103m A0A067FDQ1 PAC:18106977 Citrus sinensis 272  
orange1.1g022295m A0A067H8K0 PAC:18135956 Citrus sinensis 299  
orange1.1g027064m A0A067HH82 PAC:18135957 Citrus sinensis 229  
orange1.1g017184m A0A067H2I2 PAC:18136449 Citrus sinensis 375  
orange1.1g017438m A0A067H259 PAC:18136450 Citrus sinensis 371  
AT4G00620.1 O65271 PAC:19644764 Arabidopsis thaliana 360  
AT3G12290.1 Q9LHH7 PAC:19660871 Arabidopsis thaliana 299  
AT2G38660.2 A2RVV7 PAC:19638611 Arabidopsis thaliana 243  
AT2G38660.3 A2RVV7 PAC:19638609 Arabidopsis thaliana 352  
AT2G38660.1 A2RVV7 PAC:19638608 Arabidopsis thaliana 352  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2541774
            8485162