| Type: | Domain | Name: | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain |
| Description: | Enzymes that participate in the transfer of one-carbon units require the coenzyme tetrahydrofolate (THF). Various reactions generate one-carbon derivatives of THF, which can be interconverted between differentoxidation states by methylene-THF dehydrogenase (), methenyl-THF cyclohydrolase () and formyl-THF synthetase () [, ]. The dehydrogenase and cyclohydrolaseactivities are expressed by a variety of multifunctional enzymes, including the tri-functional eukaryotic C1-tetrahydrofolate synthase []; a bifunctional eukaryotic mitochondrial protein; and thebifunctional Escherichia colifolD protein [, ]. Methylene-tetrahydrofolate dehydrogenase andmethenyltetrahydrofolate cyclo-hydrolase share an overlapping active site [], and as such areusually located together in proteins, acting in tandem on the carbon-nitrogen bonds of substrates other than peptide bonds.This entry represents the N-terminal catalytic domain of these enzymes. | Short Name: | THF_DH/CycHdrlase_cat_dom |
| DB identifier | Type | Name |
|---|---|---|
| IPR020631 | Domain | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain |
| GO Term | Gene Name |
|---|---|
| GO:0003824 | IPR020630 |
| GO:0004488 | IPR020630 |
| GO:0009396 | IPR020630 |
| GO:0055114 | IPR020630 |
| GO Term | Gene Name |
|---|---|
| GO:0003824 | IPR020630 |
| GO:0004488 | IPR020630 |
| GO:0009396 | IPR020630 |
| GO:0055114 | IPR020630 |
