| Type: | Domain | Name: | Saccharopine dehydrogenase, NADP binding domain |
| Description: | This entry represents the NADP binding domain of saccharopine dehydrogenase. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase. The saccharopine dehydrogenase can also function as a saccharopine reductase [, ].Saccharopine dehydrogenase () catalyses the condensation of l-alpha-aminoadipate-delta-semialdehyde (AASA) with l-glutamate to give an imine, which is reduced by NADPH to give saccharopine []. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase (PF). Saccharopine dehydrogenase can also function as a saccharopine reductase. Saccharopine is an intermediate in lysine metabolism.Homospermidine synthase (HSS) () catalyses the synthesis of the polyamine homospermidine from 2 putrescine molecules in an NAD+-dependent reaction []. HSS evolved from the alternative spermidine biosynthetic pathway enzyme carboxyspermidine dehydrogenase [, ] and the structure of HSS is related to lysine metabolic enzymes []. | Short Name: | Sacchrp_dh_NADP |
