Protein Domain : IPR022674

Type:  Domain Name:  Glucose-6-phosphate dehydrogenase, NAD-binding
Description:  Glucose-6-phosphate dehydrogenase () (G6PDH) is a ubiquitous protein, present in bacteria and all eukaryotic cell types []. The enzyme catalyses thethe first step in the pentose pathway, i.e. the conversion of glucose-6-phosphate to gluconolactone 6-phosphate in the presence of NADP, producing NADPH. The ubiquitous expression of the enzyme gives it a major role in the production of NADPH for the many NADPH-mediated reductive processes in all cells []. Deficiency of G6PDH is a common genetic abnormality affecting millions of people worldwide. Many sequence variants, most caused by single point mutations, are known, exhibiting a wide variety of phenotypes [].This entry represents the NAD-binding domain of glucose-6-phosphate dehydrogenase. Short Name:  G6P_DH_NAD-bd
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0 Child Features

1 Contains

DB identifier Type Name
IPR019796 Active_site Glucose-6-phosphate dehydrogenase, active site

1 Cross References

Identifier
PF00479

1 Found In

DB identifier Type Name
IPR001282 Family Glucose-6-phosphate dehydrogenase

4 GO Annotations

GO Term Gene Name
GO:0004345 IPR022674
GO:0050661 IPR022674
GO:0006006 IPR022674
GO:0055114 IPR022674

4 Ontology Annotations

GO Term Gene Name
GO:0004345 IPR022674
GO:0050661 IPR022674
GO:0006006 IPR022674
GO:0055114 IPR022674

1 Parent Features

DB identifier Type Name
IPR016040 Domain NAD(P)-binding domain

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
150322 D8RVI7 PAC:15413202 Selaginella moellendorffii 530  
417577 D8S2X1 PAC:15404550 Selaginella moellendorffii 560  
419253 D8S8B8 PAC:15408051 Selaginella moellendorffii 575  
156908 D8SNE8 PAC:15412922 Selaginella moellendorffii 532  
446107 D8SNS4 PAC:15420115 Selaginella moellendorffii 1166  
446525 D8SS66 PAC:15423119 Selaginella moellendorffii 1183  
evm.model.supercontig_130.39 PAC:16407943 Carica papaya 407  
evm.model.supercontig_211.24 PAC:16413652 Carica papaya 601  
evm.model.supercontig_48.205 PAC:16420846 Carica papaya 485  
evm.model.supercontig_99.51 PAC:16429295 Carica papaya 431  
29929.m004613 B9RMA8 PAC:16813852 Ricinus communis 600  
30128.m008957 B9RFN8 PAC:16818542 Ricinus communis 595  
27688.m000061 B9T826 PAC:16798950 Ricinus communis 584  
28859.m000327 B9SW52 PAC:16801878 Ricinus communis 593  
Cucsa.090400.1 A0A0A0LH10 PAC:16957290 Cucumis sativus 638  
Cucsa.090400.2 PAC:16957291 Cucumis sativus 630  
Cucsa.170060.1 PAC:16966446 Cucumis sativus 473  
Cucsa.357550.1 PAC:16980425 Cucumis sativus 516  
Cucsa.357550.2 PAC:16980426 Cucumis sativus 516  
Cucsa.357550.3 PAC:16980427 Cucumis sativus 516  
Cucsa.357550.4 PAC:16980428 Cucumis sativus 492  
Cucsa.357550.5 PAC:16980429 Cucumis sativus 446  
orange1.1g018412m A0A067DGD0 PAC:18111057 Citrus sinensis 356  
orange1.1g022291m A0A067DKG2 PAC:18111058 Citrus sinensis 299  
orange1.1g010132m A0A067DGN9 PAC:18111056 Citrus sinensis 517  
orange1.1g023539m A0A067DTX3 PAC:18111059 Citrus sinensis 281  
orange1.1g041398m PAC:18134877 Citrus sinensis 196  
orange1.1g044950m PAC:18123978 Citrus sinensis 258  
orange1.1g043082m A0A067D0V5 PAC:18125377 Citrus sinensis 179  
orange1.1g038626m A0A067D341 PAC:18116011 Citrus sinensis 197  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2838391
            3393536