Protein Domain : IPR006176

Type:  Domain Name:  3-hydroxyacyl-CoA dehydrogenase, NAD binding
Description:  3-hydroxyacyl-CoA dehydrogenase () (HCDH) [] is an enzyme involved in fatty acid metabolism, it catalyzes the reduction of 3-hydroxyacyl-CoA to 3-oxoacyl-CoA. Most eukaryotic cells have 2 fatty-acid beta-oxidation systems, one located in mitochondria and the other in peroxisomes. In peroxisomes 3-hydroxyacyl-CoA dehydrogenase forms, with enoyl-CoA hydratase (ECH) and 3,2-trans-enoyl-CoA isomerase (ECI) a multifunctional enzyme where the N-terminal domain bears the hydratase/isomerase activities and the C-terminal domain the dehydrogenase activity. There are two mitochondrial enzymes: one which is monofunctional and the other which is, like its peroxisomal counterpart, multifunctional.In Escherichia coli(gene fadB) and Pseudomonas fragi(gene faoA) HCDH is part of a multifunctional enzyme which also contains an ECH/ECI domain as well as a 3-hydroxybutyryl-CoA epimerase domain [].There are two major regions of similarity in the sequences of proteins of the HCDH family, the first one located in the N-terminal, corresponds to the NAD-binding site, the second one is located in the centre of the sequence. This represents the C-terminal domain which is also found in lambda crystallin. Some proteins include two copies of this domain. Short Name:  3-OHacyl-CoA_DH_NAD-bd
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0 Child Features

0 Contains

1 Cross References

Identifier
PF02737

5 Found Ins

DB identifier Type Name
IPR022694 Family 3-hydroxyacyl-CoA dehydrogenase
IPR012802 Family Fatty oxidation complex, alpha subunit FadJ
IPR012799 Family Fatty oxidation complex, alpha subunit FadB
IPR012803 Family Fatty acid oxidation complex, alpha subunit, mitochondrial
IPR011967 Family 3-hydroxyacyl-CoA dehydrogenase PaaC

4 GO Annotations

GO Term Gene Name
GO:0003857 IPR006176
GO:0016491 IPR006176
GO:0006631 IPR006176
GO:0055114 IPR006176

4 Ontology Annotations

GO Term Gene Name
GO:0003857 IPR006176
GO:0016491 IPR006176
GO:0006631 IPR006176
GO:0055114 IPR006176

1 Parent Features

DB identifier Type Name
IPR016040 Domain NAD(P)-binding domain

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
168461 D8R530 PAC:15422138 Selaginella moellendorffii 721  
439712 D8R5A7 PAC:15403851 Selaginella moellendorffii 732  
89801 D8RAU9 PAC:15412342 Selaginella moellendorffii 273  
evm.TU.contig_38049.1 PAC:16431120 Carica papaya 188  
evm.model.supercontig_16.196 PAC:16410047 Carica papaya 722  
evm.model.supercontig_846.2 PAC:16427399 Carica papaya 263  
29726.m004067 B9RT76 PAC:16806778 Ricinus communis 541  
29912.m005496 B9RKN5 PAC:16813372 Ricinus communis 724  
Cucsa.316160.2 PAC:16977111 Cucumis sativus 633  
Cucsa.316160.1 A0A0A0KHX5 PAC:16977110 Cucumis sativus 777  
Cucsa.116420.2 PAC:16960561 Cucumis sativus 653  
Cucsa.116420.1 PAC:16960560 Cucumis sativus 724  
orange1.1g008576m A0A067FWM8 PAC:18109770 Citrus sinensis 561  
orange1.1g008604m A0A067FWG8 PAC:18109771 Citrus sinensis 560  
orange1.1g009963m A0A067G894 PAC:18109773 Citrus sinensis 521  
orange1.1g009395m A0A067FWH2 PAC:18109772 Citrus sinensis 535  
orange1.1g010109m A0A067G8L8 PAC:18109774 Citrus sinensis 518  
orange1.1g010966m A0A067G043 PAC:18109775 Citrus sinensis 496  
orange1.1g015610m A0A067G040 PAC:18109776 Citrus sinensis 403  
orange1.1g004892m A0A067DL04 PAC:18132812 Citrus sinensis 724  
orange1.1g004891m A0A067DHC5 PAC:18132810 Citrus sinensis 725  
orange1.1g004972m A0A067DUG6 PAC:18132813 Citrus sinensis 721  
orange1.1g007805m A0A067DHC7 PAC:18132814 Citrus sinensis 589  
orange1.1g009256m A0A067DGZ1 PAC:18132816 Citrus sinensis 539  
orange1.1g008509m A0A067DL06 PAC:18132815 Citrus sinensis 563  
orange1.1g004726m A0A067DT86 PAC:18132809 Citrus sinensis 733  
orange1.1g004918m A0A067DL04 PAC:18132811 Citrus sinensis 724  
orange1.1g022434m A0A067FH54 PAC:18115441 Citrus sinensis 297  
orange1.1g022407m A0A067FGE9 PAC:18115442 Citrus sinensis 297  
AT4G29010.1 Q9ZPI6 PAC:19644995 Arabidopsis thaliana 721  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2204034
            3479790