Protein Domain : IPR022694

Type:  Family Name:  3-hydroxyacyl-CoA dehydrogenase
Description:  3-hydroxyacyl-CoA dehydrogenase () (HCDH) [] is an enzyme involved in fatty acid metabolism and catalyzes the reduction of 3-hydroxyacyl-CoA to 3-oxoacyl-CoA. Most eukaryotic cells have two fatty-acid beta-oxidation systems, one located in mitochondria and the other in peroxisomes. In peroxisomes 3-hydroxyacyl-CoA dehydrogenase forms, with enoyl-CoA hydratase (ECH) and 3,2-trans-enoyl-CoA isomerase (ECI) a multifunctional enzyme where the N-terminal domain bears the hydratase/isomerase activities and the C-terminal domain the dehydrogenase activity. There are two mitochondrial enzymes: one which is monofunctional and the other which is, like its peroxisomal counterpart, multifunctional.In Escherichia coli(gene fadB) and Pseudomonas fragi(gene faoA) HCDH is part of a multifunctional enzyme which also contains an ECH/ECI domain as well as a 3-hydroxybutyryl-CoA epimerase domain []. Short Name:  3-OHacyl-CoA_DH
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0 Child Features

6 Contains

DB identifier Type Name
IPR016040 Domain NAD(P)-binding domain
IPR013328 Domain 6-phosphogluconate dehydrogenase, domain 2
IPR008927 Domain 6-phosphogluconate dehydrogenase C-terminal domain-like
IPR006176 Domain 3-hydroxyacyl-CoA dehydrogenase, NAD binding
IPR006108 Domain 3-hydroxyacyl-CoA dehydrogenase, C-terminal
IPR006180 Conserved_site 3-hydroxyacyl-CoA dehydrogenase, conserved site

1 Cross References

Identifier
PIRSF000105

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003857 IPR022694
GO:0070403 IPR022694
GO:0006631 IPR022694
GO:0055114 IPR022694

4 Ontology Annotations

GO Term Gene Name
GO:0003857 IPR022694
GO:0070403 IPR022694
GO:0006631 IPR022694
GO:0055114 IPR022694

0 Parent Features

325 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_80.84 PAC:16426812 Carica papaya 350  
29668.m000313 B9SQH3 PAC:16805203 Ricinus communis 296  
Cucsa.032520.1 PAC:16952462 Cucumis sativus 296  
orange1.1g022434m A0A067FH54 PAC:18115441 Citrus sinensis 297  
orange1.1g022407m A0A067FGE9 PAC:18115442 Citrus sinensis 297  
AT3G15290.1 Q9LDF5 PAC:19662080 Arabidopsis thaliana 294  
Thhalv10021099m V4NPH4 PAC:20183936 Eutrema salsugineum 335  
Ciclev10009049m V4ULA7 PAC:20794621 Citrus clementina 297  
Lus10012681 PAC:23148219 Linum usitatissimum 290  
Lus10020828 PAC:23177991 Linum usitatissimum 290  
Potri.001G398600.2 A0A2K2CB23 PAC:27042299 Populus trichocarpa 295  
Potri.001G398600.1 A0A2K2CB23 PAC:27042300 Populus trichocarpa 295  
Gorai.002G068600.1 A0A0D2Q8W3 PAC:26794461 Gossypium raimondii 296  
Thecc1EG031591t1 A0A061F847 PAC:27445654 Theobroma cacao 296  
Migut.M00789.1.p A0A022RY93 PAC:28948607 Mimulus guttatus 286  
Araha.0665s0002.1.p PAC:28863157 Arabidopsis halleri 291  
Cagra.0007s0071.1.p PAC:28903147 Capsella grandiflora 294  
Glyma.06G254700.1.p B0M194 PAC:30550525 Glycine max 319  
Glyma.06G238900.1.p A0A0R0JSV2 PAC:30550561 Glycine max 249  
Brara.E02612.1.p A0A397ZDT7 PAC:30626904 Brassica rapa FPsc 294  
Bostr.28625s0191.1.p PAC:30679351 Boechera stricta 294  
Cre12.g534350.t1.2 A0A2K3D509 PAC:30791852 Chlamydomonas reinhardtii 320  
Medtr8g058775.1 PAC:31076344 Medicago truncatula 296  
Medtr8g061230.1 PAC:31072865 Medicago truncatula 296  
SapurV1A.1264s0030.1.p PAC:31436466 Salix purpurea 295  
Spipo1G0117700 PAC:31520951 Spirodela polyrhiza 300  
evm_27.model.AmTr_v1.0_scaffold00183.2 U5D5K2 PAC:31560549 Amborella trichopoda 296  
Traes_1AS_CDB7F0AA6.8 PAC:31764134 Triticum aestivum 341  
Traes_1AS_CDB7F0AA6.10 PAC:31764135 Triticum aestivum 341  
Traes_1AS_CDB7F0AA6.12 PAC:31764136 Triticum aestivum 341  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2204034
            3479790