Protein Domain : IPR012351

Type:  Domain Name:  Four-helical cytokine, core
Description:  This entry represents a 4-helical bundle domain found predominantly in long- and short-chain cytokines, such as interleukins, interferons, growth hormones, and granulocyte colony stimulating factors. Cytokines play a crucial role in the development of an immune response by organising the recruitment and trafficking of immune cell populations throughout the body, usually through GPCR signalling []. Most cytokines have a predominantly alpha helical structure, and share a core domain consisting of a closed bundle of four helices in a left-handed twist, with two crossover connections []. Short Name:  4_helix_cytokine_core
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0 Child Features

4 Contains

DB identifier Type Name
IPR020423 Conserved_site Interleukin-10, conserved site
IPR018116 Conserved_site Somatotropin hormone, conserved site
IPR019767 Conserved_site Erythropoietin/thrombopoeitin, conserved site
IPR019827 Conserved_site Leukemia inhibitory factor /oncostatin, conserved site

1 Cross References

Identifier
G3DSA:1.20.1250.10

27 Found Ins

DB identifier Type Name
IPR000779 Family Interleukin-2
IPR001581 Family Leukemia inhibitory factor /oncostatin
IPR002069 Family Interferon gamma
IPR000186 Family Interleukin-5
IPR000773 Family Granulocyte-macrophage colony-stimulating factor
IPR020443 Family Interleukin-10/19/20/24/26 family
IPR004213 Family Flt3 ligand
IPR004281 Family Interleukin-12 alpha
IPR002183 Family Interleukin-3
IPR000151 Family Ciliary neurotrophic factor, CNTF
IPR000098 Family Interleukin-10
IPR000065 Family Leptin
IPR003574 Family Interleukin-6
IPR010831 Family Interleukin-23 alpha
IPR001400 Family Somatotropin hormone
IPR003624 Family Leukemia inhibitory factor
IPR003452 Family Stem cell factor
IPR020421 Family Interleukin-19
IPR020442 Family Interleukin-20
IPR020444 Family Interleukin-24
IPR020453 Family Interleukin-22
IPR000471 Family Interferon alpha/beta/delta
IPR001323 Family Erythropoietin/thrombopoeitin
IPR015588 Family Interferon beta
IPR003013 Family Erythropoietin
IPR015589 Family Interferon alpha
IPR003978 Family Thrombopoeitin

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR009079 Domain Four-helical cytokine-like, core

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
96204 D8RLS1 PAC:15406111 Selaginella moellendorffii 340  
441756 D8RMC8 PAC:15410246 Selaginella moellendorffii 586  
404292 D8QUV9 PAC:15408714 Selaginella moellendorffii 149  
98811 D8RQM2 PAC:15416590 Selaginella moellendorffii 637  
57477 D8RS23 PAC:15404206 Selaginella moellendorffii 133  
414920 D8RU03 PAC:15421081 Selaginella moellendorffii 393  
271113 D8RV05 PAC:15420854 Selaginella moellendorffii 90  
405079 D8QYB8 PAC:15410152 Selaginella moellendorffii 336  
416938 D8S0V5 PAC:15404597 Selaginella moellendorffii 276  
423707 D8SMM1 PAC:15401510 Selaginella moellendorffii 398  
425516 D8STC7 PAC:15405817 Selaginella moellendorffii 911  
409395 D8RBB5 PAC:15401826 Selaginella moellendorffii 384  
evm.TU.contig_32354.1 PAC:16430096 Carica papaya 135  
evm.model.supercontig_103.6 PAC:16404946 Carica papaya 88  
evm.model.supercontig_106.40 PAC:16405205 Carica papaya 485  
evm.model.supercontig_11.11 PAC:16405596 Carica papaya 363  
evm.model.supercontig_153.1 PAC:16409673 Carica papaya 135  
evm.model.supercontig_16.165 PAC:16410013 Carica papaya 146  
evm.model.supercontig_1872.2 PAC:16411742 Carica papaya 614  
evm.model.supercontig_198.42 PAC:16412407 Carica papaya 137  
evm.model.supercontig_21.11 PAC:16413381 Carica papaya 226  
evm.model.supercontig_29.103 PAC:16416126 Carica papaya 180  
evm.model.supercontig_3.426 PAC:16416731 Carica papaya 311  
evm.model.supercontig_35.59 PAC:16418179 Carica papaya 428  
evm.model.supercontig_43.109 PAC:16419917 Carica papaya 327  
evm.model.supercontig_7.51 PAC:16425213 Carica papaya 531  
evm.model.supercontig_8.271 PAC:16426565 Carica papaya 478  
evm.model.supercontig_89.46 PAC:16427921 Carica papaya 305  
29734.m000418 B9SKY1 PAC:16807107 Ricinus communis 845  
29767.m000204 B9SYB7 PAC:16808237 Ricinus communis 175  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9118960
            12466283