Protein Domain : IPR009079

Type:  Domain Name:  Four-helical cytokine-like, core
Description:  This domain displays a core structure consisting of a closed bundle of four helices in a left-handed twist, with two crossover connections. Proteins containing this domain include long-chain cytokines, such as leukaemia inhibitory factor (LIF) [], the growth hormone somatotropin [], interleukin-6 [] and leptin []; short-chain cytokines, such as erythropoietin [], stem cell factor (SCF) [], macrophage colony-stimulating factor (M-CSF) and interleukin-2, -3, -4, -5 and -13; and interferons/interleukin-10. Short Name:  4_helix_cytokine-like_core
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1 Child Features

DB identifier Type Name
IPR012351 Domain Four-helical cytokine, core

6 Contains

DB identifier Type Name
IPR012352 Domain Interleukin-10, additional helical
IPR018096 Conserved_site Interleukin-4/interleukin-13, conserved site
IPR020423 Conserved_site Interleukin-10, conserved site
IPR018116 Conserved_site Somatotropin hormone, conserved site
IPR019767 Conserved_site Erythropoietin/thrombopoeitin, conserved site
IPR019827 Conserved_site Leukemia inhibitory factor /oncostatin, conserved site

1 Cross References

Identifier
SSF47266

4 Found Ins

DB identifier Type Name
IPR004213 Family Flt3 ligand
IPR000151 Family Ciliary neurotrophic factor, CNTF
IPR003452 Family Stem cell factor
IPR008001 Family Macrophage colony stimulating factor-1

0 GO Annotation

0 Ontology Annotations

0 Parent Features

101 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_87.45 PAC:16427713 Carica papaya 160  
orange1.1g043821m A0A067FLQ0 PAC:18099284 Citrus sinensis 104  
Gorai.004G169100.1 A0A0D2QZ06 PAC:26772904 Gossypium raimondii 313  
55062 C1MJR1 PAC:27342690 Micromonas pusilla CCMP1545 507  
Brara.F00302.4.p A0A397Z3K9 PAC:30628895 Brassica rapa FPsc 404  
Brara.F00302.2.p A0A397Z3K9 PAC:30628894 Brassica rapa FPsc 404  
Brara.F00302.3.p A0A397Z3K9 PAC:30628892 Brassica rapa FPsc 404  
Brara.F00302.1.p A0A397Z3K9 PAC:30628893 Brassica rapa FPsc 404  
evm_27.model.AmTr_v1.0_scaffold00063.55 U5D7D3 PAC:31569051 Amborella trichopoda 436  
Eucgr.E02883.1.p A0A059C7R7 PAC:32030118 Eucalyptus grandis 282  
Kalax.1120s0001.2.p PAC:32534710 Kalanchoe laxiflora 1062  
Kalax.1201s0002.2.p PAC:32534116 Kalanchoe laxiflora 1062  
Brdisv1Gaz-81003366m.p PAC:33806272 Brachypodium distachyon Gaz-8 198  
Brdisv1Bd30-11032730m.p PAC:34049805 Brachypodium distachyon Bd30-1 198  
Brdisv1ABR81006208m.p PAC:34570008 Brachypodium distachyon ABR8 198  
Brdisv1Koz-31039589m.p PAC:35144292 Brachypodium distachyon Koz-3 198  
Brdisv1Sig21006612m.p PAC:35250769 Brachypodium distachyon Sig2 198  
Kaladp0004s0016.2.p PAC:35768197 Kalanchoe fedtschenkoi 1062  
DCAR_020401 PAC:36085085 Daucus carota 230  
Solyc03g062680.2.1 PAC:36136795 Solanum lycopersicum 209  
Oeu058865.1 PAC:37734034 Olea europaea 202  
Oeu005324.1 PAC:37745444 Olea europaea 370  
evm.model.Scaffold_637.1507 PAC:37877029 Coffea arabica 491  
evm.model.Scaffold_637.1406 PAC:37877261 Coffea arabica 243  
Gohir.A08G141600.1.p PAC:38157821 Gossypium hirsutum 313  
Gohir.D09G075800.1.p PAC:38123171 Gossypium hirsutum 85  
HORVU2Hr1G016470.24 PAC:38355731 Hordeum vulgare 105  
HORVU2Hr1G016470.13 PAC:38355728 Hordeum vulgare 110  
HORVU2Hr1G016470.26 PAC:38355729 Hordeum vulgare 109  
HORVU2Hr1G016470.29 PAC:38355730 Hordeum vulgare 109  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14507421
            14511776
            9118960
            9783743
            10880433
            9144295