Protein Domain : IPR000773

Type:  Family Name:  Granulocyte-macrophage colony-stimulating factor
Description:  Granulocyte-macrophage colony-stimulating factor (GMCSF) is a cytokine that acts in hematopoiesis to stimulate growth and differentiation of hematopoietic precursor cellsfrom various lineages including granulocytes, macrophages, eosinophils and erythrocytes [, ]. GMCSF is a glycoprotein of ~120 residues that contains 4 conservedcysteines that participate in disulphide bond formation. The crystal structure of recombinant human GMCSF has been determined []. There are two molecules in the asymmetricunit, which are related by an approximate non-crystallographic 2-fold axis. The overall structure, which is highly compact and globular with a predominantly hydrophobic core, ischaracterised by a 4-alpha-helix bundle. The helices are arranged in a left-handed anti-parallel fashion, with two overhand connections. Within the connections is a two-stranded anti-parallel beta-sheet. The tertiary structure has a topology similar to that of Sus scrofa(pig) growth factor and interferon-beta. Most of the proposed critical regions for receptor binding arelocated on a continuous surface at one end of the molecule that includes the C terminus []. Short Name:  GM_colony-stim-fac
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0 Child Features

1 Contains

DB identifier Type Name
IPR012351 Domain Four-helical cytokine, core

6 Cross Referencess

Identifier
PTHR10059
PF01109
PR00693
PD007349
PS00702
SM00040

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0005129 IPR000773
GO:0008083 IPR000773
GO:0006955 IPR000773
GO:0005576 IPR000773

4 Ontology Annotations

GO Term Gene Name
GO:0005129 IPR000773
GO:0008083 IPR000773
GO:0006955 IPR000773
GO:0005576 IPR000773

0 Parent Features

9 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Zm00008a014544_P01 PAC:37184520 Zea mays PH207 535  
Zm00008a032781_P01 PAC:37192641 Zea mays PH207 156  
Zm00001d044363_P001 A0A1D6NL77 PAC:40232336 Zea mays 682  
Zm00001d044363_P003 A0A1D6NL79 PAC:40232334 Zea mays 797  
Misin06G345300.1.p PAC:40463973 Miscanthus sinensis 156  
Thint.09G0269900.1.p PAC:40821493 Thinopyrum intermedium 101  
ZmPHJ40.K509700.1.p PAC:41373943 Zea mays PHJ40 189  
ZmPHB47.08G272800.1.p PAC:41427933 Zea mays PHB47 156  
Pavag03G356100.1.p PAC:50320398 Paspalum vaginatum 155  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2458827
            1569568