Protein Domain : IPR000186

Type:  Family Name:  Interleukin-5
Description:  This entry represents interleukin-5 (IL5), also known as eosinophil differentiation factor (EDF), is a lineage-specific cytokine for eosinophilpoiesis [, ]. It regulates eosinophil growth and activation [], and thus plays an important role indiseases associated with increased levels of eosinophils, including asthma []. IL5 has a similar overall fold to other cytokines (e.g., IL2, IL4 and GCSF) [], but while these exist as monomeric structures, IL5 is a homodimer. Thefold contains an anti-parallel 4-alpha-helix bundle with a left handed twist, connected by a 2-stranded anti-parallel beta-sheet [, ]. The monomers areheld together by 2 interchain disulphide bonds []. Short Name:  IL-5
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0 Child Features

1 Contains

DB identifier Type Name
IPR012351 Domain Four-helical cytokine, core

4 Cross Referencess

Identifier
PTHR10525
PF02025
PR00432
PD006721

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0005137 IPR000186
GO:0008083 IPR000186
GO:0006955 IPR000186
GO:0005576 IPR000186

4 Ontology Annotations

GO Term Gene Name
GO:0005137 IPR000186
GO:0008083 IPR000186
GO:0006955 IPR000186
GO:0005576 IPR000186

0 Parent Features

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Tp57577_TGAC_v2_mRNA13212 PAC:35987319 Trifolium pratense 560  
Nycol.K00712.1.p PAC:44518458 Nymphaea colorata 247  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2037074
            8483502
            3498940