3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0005125 | IPR000098 |
| GO:0006955 | IPR000098 |
| GO:0005576 | IPR000098 |
| Type: | Family | Name: | Interleukin-10 |
| Description: | Interleukin 10 (IL-10) is a secreted 17-21kDa protein that is non- glycosylated in humans but exists as a non-covalent homodimer. IL-10 issecreted by some types of T-lymphocyte, B-lymphocytes and macrophages late after antigen activation. Generally, IL-10 inhibits T-cell and natural killer cell synthesis of other cytokines at the transcriptional level, indirectly, by affecting macrophages. These cytokines include interferon-gamma, IL-2, IL-3, tumour necrosis factor and granulocyte-macrophage colony-stimulating factor(GM-CSF). The mechanism of IL-10 induced inhibition appears to involve a reduction in the abundance of the macrophage surface molecules that directlystimulate T-cells and natural killer cells. Proteins encoded by viruses such as Epstein-Barr virus and equine herpes virus show a high degree of sequence identity to IL-10. These proteins are thought to be involved in evasion of host immune responses. The IL-10 molecule is a tight dimer of 2 interpenetrating subunits that form a V-shaped structure. Each half of the structure consists of 6 alpha-helices (4 from 1 subunit and 2 from the other). Four of the helices form an up-up-down-down bundle, which is observed in all other helical cytokines. The overall topology resembles interferon-gamma.This entry represents interleukin-10. | Short Name: | IL-10 |
| GO Term | Gene Name |
|---|---|
| GO:0005125 | IPR000098 |
| GO:0006955 | IPR000098 |
| GO:0005576 | IPR000098 |
