| Type: | Family | Name: | Interleukin-2 |
| Description: | T-Lymphocytes regulate the growth and differentiation of certain lymphopoietic and haemopoietic cells through the release of various secreted protein factors [].These factors, which include interleukin-2 (IL2), are secreted by lectin- or antigen-stimulated T-cells, and have various physiological effects. IL2 is a lymphokine that induces theproliferation of responsive T-cells. In addition, it acts on some B-cells, via receptor-specific binding [], as a growth factor and antibody production stimulant []. Theprotein is secreted as a single glycosylated polypeptide, and cleavage of a signal sequence is required for its activity []. Solution NMR suggests that the structure of IL2 comprises abundle of 4 helices (termed A-D), flanked by 2 shorter helices and several poorly-defined loops. Residues in helix A, and in the loop region between helices A and B, are important forreceptor binding. Secondary structure analysis has suggested similarity to IL4 and granulocyte-macrophage colony stimulating factor (GMCSF) []. | Short Name: | IL-2 |
| GO Term | Gene Name |
|---|---|
| GO:0005134 | IPR000779 |
| GO:0008083 | IPR000779 |
| GO:0006955 | IPR000779 |
| GO:0005576 | IPR000779 |
| GO Term | Gene Name |
|---|---|
| GO:0005134 | IPR000779 |
| GO:0008083 | IPR000779 |
| GO:0006955 | IPR000779 |
| GO:0005576 | IPR000779 |
| DB identifier | UniProt Accession | Secondary Identifier | Organism Name | Length |
|---|---|---|---|---|
| Glyma.11G172600.1.p | A0A0R0HRZ7 | PAC:30528927 | Glycine max |
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