Protein Domain : IPR002183

Type:  Family Name:  Interleukin-3
Description:  Interleukin-3 (IL3) is a cytokine that regulates blood-cell production by controlling the production, differentiation and function of granulocytes and macrophages [, ]. The protein, which exists in vivo as a monomer, is produced in activated T-cells and mast cells [, ], and is activated by the cleavage of an N-terminal signal sequence [].IL3 is produced by T-lymphocytes and T-lymphomas only after stimulation with antigens, mitogens, or chemical activators such as phorbol esters. However, IL3 is constitutively expressed in the myelomonocytic leukaemia cell line WEHI-3B []. It is thought that the genetic change of the cell line to constitutive production of IL3 is the key event in development of this leukaemia []. Short Name:  IL-3
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0 Child Features

1 Contains

DB identifier Type Name
IPR012351 Domain Four-helical cytokine, core

4 Cross Referencess

Identifier
PTHR10079
PF02059
PIRSF001939
PR00430

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0005135 IPR002183
GO:0008083 IPR002183
GO:0006955 IPR002183
GO:0005576 IPR002183

4 Ontology Annotations

GO Term Gene Name
GO:0005135 IPR002183
GO:0008083 IPR002183
GO:0006955 IPR002183
GO:0005576 IPR002183

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3497843
            2413359