Protein Domain : IPR020568

Type:  Domain Name:  Ribosomal protein S5 domain 2-type fold
Description:  Domain 2 of the ribosomal protein S5 has a left-handed, 2-layer alpha/beta fold with a core structure consisting of beta(3)-alpha-beta-alpha. Domains with this fold are found in numerous RNA/DNA-binding proteins, as well as in kinases from the GHMP kinase family. Proteins containing this alpha/beta fold domain include: Translational machinery components (ribosomal proteins S5 and S9, and domain IV of elongation factors EF-G and eEF-2) [].Ribonuclease P protein (RNase P) [].Ribonuclease PH (domain 1) [], as well as various exosome complex exonucleases (RRP41, RRP42, RRP43, RRP45, RRP46, MTR3, ECX1, ECX2) [].DNA modification proteins (DNA mismatch repair proteins MutL and PMS2, DNA gyrase B, DNA topoisomerase II, IV-B and VI-B) []. GHMP kinases that transfer a phosphoryl group from ATP to an acceptor (galactokinase (), homoserine kinase (), and mevalonate kinase ()) [, ].Caenorhabditis elegansearly switch protein Xol-1 (a divergent member of the GHMP kinase family that has lost the ATP-binding site) [].Hsp90 chaperone (middle domain), which is related to the DNA gyrase/MutL family []; this domain contains an extra C-terminal alpha/beta subdomain.Imidazole glycerol phosphate dehydratase, which contains a duplication consisting of two structural repeats of this fold [].The catalytic domain of ATP-dependent protease Lon (La), which contains an extra C-terminal alpha/beta subdomain [].Formaldehyde-activating enzyme FAE, which contains a modification of this fold consisting of an extra alpha/beta unit after strand 2 []. Short Name:  Ribosomal_S5_D2-typ_fold
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6 Child Features

DB identifier Type Name
IPR001247 Domain Exoribonuclease, phosphorolytic domain 1
IPR001498 Domain Impact, N-terminal
IPR014721 Domain Ribosomal protein S5 domain 2-type fold, subgroup
IPR008269 Domain Peptidase S16, Lon C-terminal
IPR011334 Domain UDP-3-O-acyl N-acetylglucosamine deacetylase, C-terminal
IPR015870 Domain UDP-3-O-acyl N-acetylglucosamine deacetylase, N-terminal

10 Contains

DB identifier Type Name
IPR006204 Domain GHMP kinase N-terminal domain
IPR019539 Domain Galactokinase galactose-binding domain
IPR008268 Active_site Peptidase S16, active site
IPR018336 Conserved_site Ribonuclease PH, conserved site
IPR020574 Conserved_site Ribosomal protein S9, conserved site
IPR006203 Conserved_site GHMP kinase, ATP-binding, conserved site
IPR020539 Conserved_site Ribonuclease P, conserved site
IPR019741 Conserved_site Galactokinase, conserved site
IPR020565 Conserved_site Imidazoleglycerol-phosphate dehydratase, conserved site
IPR020569 Conserved_site Uncharacterised protein family UPF0029, Impact, conserved site

1 Cross References

Identifier
SSF54211

44 Found Ins

DB identifier Type Name
IPR000705 Family Galactokinase
IPR005935 Family Diphosphomevalonate/phosphomevalonate decarboxylase
IPR004463 Family UDP-3-O-acyl N-acetylglucosamine deacetylase
IPR016005 Family Phosphomevalonate kinase, ERG8
IPR000807 Family Imidazoleglycerol-phosphate dehydratase
IPR004424 Family 4-diphosphocytidyl-2C-methyl-D-erythritol kinase
IPR012162 Family Polyribonucleotide nucleotidyltransferase
IPR011186 Family DNA mismatch repair protein Mlh1/HexB
IPR002099 Family DNA mismatch repair protein family
IPR001404 Family Heat shock protein Hsp90 family
IPR005734 Family DNA topoisomerase VI, subunit B
IPR004540 Family Translation elongation factor EFG/EF2
IPR000851 Family Ribosomal protein S5
IPR001241 Family DNA topoisomerase, type IIA
IPR004504 Family DNA repair protein RadA
IPR006206 Family Mevalonate/galactokinase
IPR001174 Family Galactokinase/homoserine kinase
IPR004815 Family Lon protease, bacterial/eukaryotic-type
IPR005711 Family Ribosomal protein S5, eukaryotic/archaeal
IPR006205 Family Mevalonate kinase
IPR011557 Family DNA gyrase, subunit B
IPR000565 Family DNA topoisomerase, type IIA, subunit B
IPR012369 Family Galactokinase, glycosyltransferase
IPR005712 Family Ribosomal protein S5, bacterial-type
IPR004482 Family Mg chelatase-related protein
IPR005737 Family DNA topoisomerase IV, subunit B, Gram-negative
IPR002381 Family Ribonuclease phosphorolytic, bacterial-type
IPR005740 Family DNA topoisomerase 4 subunit B, Gram-positive
IPR014069 Family Guanosine pentaphosphate synthetase I/polyribonucleotide nucleotidyltransferase
IPR004543 Family Translation elongation factor EFG/EF2, archaeal

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
171139 D8RFY2 PAC:15406567 Selaginella moellendorffii 705  
231460 D8RFX7 PAC:15416814 Selaginella moellendorffii 982  
267300 D8RF63 PAC:15410445 Selaginella moellendorffii 691  
440901 D8RF85 PAC:15408618 Selaginella moellendorffii 867  
92654 D8RF35 PAC:15419953 Selaginella moellendorffii 655  
411087 D8RGJ4 PAC:15405592 Selaginella moellendorffii 842  
138369 D8TF39 PAC:15422105 Selaginella moellendorffii 144  
141453 D8QWC2 PAC:15409675 Selaginella moellendorffii 694  
230099 D8QUE5 PAC:15410961 Selaginella moellendorffii 909  
404176 D8QUH9 PAC:15407859 Selaginella moellendorffii 187  
404241 D8QUQ5 PAC:15408580 Selaginella moellendorffii 103  
404437 D8QVB7 PAC:15410202 Selaginella moellendorffii 215  
404562 D8QVQ8 PAC:15411072 Selaginella moellendorffii 155  
68940 D8QVQ6 PAC:15418184 Selaginella moellendorffii 98  
68894 D8QVQ9 PAC:15417547 Selaginella moellendorffii 131  
413292 D8RNZ7 PAC:15413103 Selaginella moellendorffii 591  
98330 D8RNR7 PAC:15412854 Selaginella moellendorffii 1151  
413630 D8RQW5 PAC:15416015 Selaginella moellendorffii 594  
98813 D8RQV9 PAC:15416593 Selaginella moellendorffii 588  
98990 D8RPS9 PAC:15417582 Selaginella moellendorffii 964  
413887 D8RQY4 PAC:15417639 Selaginella moellendorffii 339  
102800 D8RVL9 PAC:15409076 Selaginella moellendorffii 288  
141788 D8QWE3 PAC:15412071 Selaginella moellendorffii 879  
230177 D8QXF6 PAC:15411643 Selaginella moellendorffii 669  
30423 D8QXF0 PAC:15414090 Selaginella moellendorffii 928  
67484 D8QXW6 PAC:15411576 Selaginella moellendorffii 263  
79886 D8QWR9 PAC:15405250 Selaginella moellendorffii 145  
80529 D8QWZ7 PAC:15406034 Selaginella moellendorffii 250  
416617 D8RZV8 PAC:15402325 Selaginella moellendorffii 584  
416615 D8RZV6 PAC:15402322 Selaginella moellendorffii 679  

12 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8722013
            17174896
            11188689
            12672694
            11574484
            17081993
            15544330
            15039704
            14724278
            14767080
            14665623
            15632161