Protein Domain : IPR014721

Type:  Domain Name:  Ribosomal protein S5 domain 2-type fold, subgroup
Description:  Domain 2 of the ribosomal protein S5 has a left-handed beta-alpha-beta fold that is found in numerous RNA/DNA-binding proteins, as well as in kinases from the GHMP kinase family. Proteins containing this beta-alpha-beta fold domain include: Translational machinery components (ribosomal proteins S5 and S9, and domain IV of elongation factors EF-G and eEF-2) [].Ribonuclease P protein (RNase P) [].DNA modification proteins (DNA mismatch repair proteins MutL and PMS2, DNA gyrase B, DNA topoisomerase II, IV-B and VI-B) [].GHMP kinases that transfer a phosphoryl group from ATP to an acceptor (galactokinase (), homoserine kinase (), and mevalonate kinase ()) [, ].Caenorhabditis elegansearly switch protein Xol-1 (a divergent member of the GHMP kinase family that has lost the ATP-binding site) []. Short Name:  Ribosomal_S5_D2-typ_fold_subgr
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6 Child Features

DB identifier Type Name
IPR005517 Domain Translation elongation factor EFG/EF2, domain IV
IPR013507 Domain DNA mismatch repair protein, C-terminal
IPR015320 Domain DNA topoisomerase VI, subunit B, transducer
IPR005324 Domain Ribosomal protein S5, C-terminal
IPR013506 Domain DNA topoisomerase, type IIA, subunit B, domain 2
IPR015192 Domain Switch protein XOL-1, N-terminal

6 Contains

DB identifier Type Name
IPR006204 Domain GHMP kinase N-terminal domain
IPR019539 Domain Galactokinase galactose-binding domain
IPR020574 Conserved_site Ribosomal protein S9, conserved site
IPR006203 Conserved_site GHMP kinase, ATP-binding, conserved site
IPR020539 Conserved_site Ribonuclease P, conserved site
IPR019741 Conserved_site Galactokinase, conserved site

1 Cross References

Identifier
G3DSA:3.30.230.10

17 Found Ins

DB identifier Type Name
IPR000705 Family Galactokinase
IPR005935 Family Diphosphomevalonate/phosphomevalonate decarboxylase
IPR016005 Family Phosphomevalonate kinase, ERG8
IPR000870 Family Homoserine kinase
IPR004424 Family 4-diphosphocytidyl-2C-methyl-D-erythritol kinase
IPR002099 Family DNA mismatch repair protein family
IPR005734 Family DNA topoisomerase VI, subunit B
IPR004540 Family Translation elongation factor EFG/EF2
IPR006206 Family Mevalonate/galactokinase
IPR001174 Family Galactokinase/homoserine kinase
IPR006205 Family Mevalonate kinase
IPR012369 Family Galactokinase, glycosyltransferase
IPR004543 Family Translation elongation factor EFG/EF2, archaeal
IPR020667 Family DNA mismatch repair protein, MutL
IPR010189 Family Shikimate kinase, archaea
IPR005917 Family Phosphomevalonate kinase, Gram-positive
IPR014606 Family D,D-heptose 7-phosphate kinase

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR020568 Domain Ribosomal protein S5 domain 2-type fold

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
171139 D8RFY2 PAC:15406567 Selaginella moellendorffii 705  
92654 D8RF35 PAC:15419953 Selaginella moellendorffii 655  
138369 D8TF39 PAC:15422105 Selaginella moellendorffii 144  
404176 D8QUH9 PAC:15407859 Selaginella moellendorffii 187  
413630 D8RQW5 PAC:15416015 Selaginella moellendorffii 594  
98813 D8RQV9 PAC:15416593 Selaginella moellendorffii 588  
414063 D8RRI4 PAC:15414447 Selaginella moellendorffii 546  
141788 D8QWE3 PAC:15412071 Selaginella moellendorffii 879  
30423 D8QXF0 PAC:15414090 Selaginella moellendorffii 928  
405160 D8QWE9 PAC:15410905 Selaginella moellendorffii 432  
67484 D8QXW6 PAC:15411576 Selaginella moellendorffii 263  
79886 D8QWR9 PAC:15405250 Selaginella moellendorffii 145  
416617 D8RZV8 PAC:15402325 Selaginella moellendorffii 584  
416615 D8RZV6 PAC:15402322 Selaginella moellendorffii 679  
416661 D8S004 PAC:15402420 Selaginella moellendorffii 171  
416649 D8RZZ2 PAC:15402381 Selaginella moellendorffii 516  
416656 D8RZZ9 PAC:15402399 Selaginella moellendorffii 518  
82887 D8R2P9 PAC:15414450 Selaginella moellendorffii 657  
85905 D8R6P0 PAC:15401350 Selaginella moellendorffii 50  
17067 D8RC23 PAC:15417100 Selaginella moellendorffii 162  
428850 D8T477 PAC:15417047 Selaginella moellendorffii 176  
428849 D8T475 PAC:15417032 Selaginella moellendorffii 129  
evm.TU.contig_44864.1 PAC:16432102 Carica papaya 56  
evm.model.supercontig_1.357 PAC:16404296 Carica papaya 269  
evm.model.supercontig_1.394 PAC:16404337 Carica papaya 404  
evm.model.supercontig_13.284 PAC:16407807 Carica papaya 123  
evm.model.supercontig_26.286 PAC:16415234 Carica papaya 107  
evm.model.supercontig_2949.1 PAC:16416344 Carica papaya 139  
evm.model.supercontig_34.168 PAC:16417902 Carica papaya 484  
evm.model.supercontig_464.3 PAC:16420587 Carica papaya 310  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8722013
            11188689
            12672694
            11574484
            17081993
            15544330