| Type: | Family | Name: | DNA mismatch repair protein, MutL |
| Description: | Mismatch repair is one of five major DNA repair pathways, the others being homologous recombination repair, non-homologous end joining, nucleotide excision repair, and base excision repair. The mismatch repair system recognises and repairs mispaired or unpaired nucleotides that result from errors in DNA replication. Many proteins involved in the different repair processes also play a role in apoptosis when DNA damage is excessive, thereby helping to prevent carcinogenesis []. The mismatch repair protein, Mlh1 (mutL homologue 1), has a dual role in DNA repair and apoptosis. Mlh1 acts as a heterodimer in conjunction with Pms2, Pms1 (post-meiotic segregation 1 and 2) or Mlh3 (MutL homologue 3), which function as adaptor proteins that link Msh (MutS homologue) heterodimers to the DNA repair machinery, resulting in excision and repair of the mispaired base [].This entry represents the mismatch repair protein MutL. | Short Name: | DNA_mismatch_repair_MutL |
| DB identifier | Type | Name |
|---|---|---|
| IPR003594 | Domain | Histidine kinase-like ATPase, C-terminal domain |
| IPR020568 | Domain | Ribosomal protein S5 domain 2-type fold |
| IPR014721 | Domain | Ribosomal protein S5 domain 2-type fold, subgroup |
| IPR013507 | Domain | DNA mismatch repair protein, C-terminal |
| IPR014790 | Domain | MutL, C-terminal, dimerisation |
| IPR014762 | Conserved_site | DNA mismatch repair, conserved site |
