Protein Domain : IPR000705

Type:  Family Name:  Galactokinase
Description:  Galactokinase catalyses the first reaction in the galactose metabolism pathway, the ATP-dependent phosphorylation of galactose, yielding galactose-1-phosphate [, ].Deficiency in this enzyme results in the disease galactosemia, which is responsible for the formation of cataracts in newborn babies, and is possibly responsible for presenile cataracts inadults []. In yeast, the GAL3 gene product is required for the GAL4-mediated inductionof other enzymes involved in galactose metabolism. The induction of GAL1 production then reinforces this process, increasing the expression of other galactose-inducible genes. GAL3 has been shown tobe similar to the GAL1 protein []. Short Name:  Galactokinase
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1 Child Features

DB identifier Type Name
IPR022963 Family Galactokinase, bacterial

7 Contains

DB identifier Type Name
IPR020568 Domain Ribosomal protein S5 domain 2-type fold
IPR013750 Domain GHMP kinase, C-terminal domain
IPR006204 Domain GHMP kinase N-terminal domain
IPR014721 Domain Ribosomal protein S5 domain 2-type fold, subgroup
IPR019539 Domain Galactokinase galactose-binding domain
IPR006203 Conserved_site GHMP kinase, ATP-binding, conserved site
IPR019741 Conserved_site Galactokinase, conserved site

3 Cross Referencess

Identifier
PIRSF000530
PR00473
TIGR00131

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004335 IPR000705
GO:0005524 IPR000705
GO:0006012 IPR000705
GO:0046835 IPR000705

4 Ontology Annotations

GO Term Gene Name
GO:0004335 IPR000705
GO:0005524 IPR000705
GO:0006012 IPR000705
GO:0046835 IPR000705

1 Parent Features

DB identifier Type Name
IPR006206 Family Mevalonate/galactokinase

991 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
82393 D8QZX0 PAC:15410622 Selaginella moellendorffii 426  
144964 D8R9V7 PAC:15422206 Selaginella moellendorffii 505  
evm.model.supercontig_115.46 PAC:16406211 Carica papaya 441  
evm.model.supercontig_9.29 PAC:16428190 Carica papaya 406  
29889.m003324 B9RZT4 PAC:16812271 Ricinus communis 499  
30162.m001270 B9RKW5 PAC:16820949 Ricinus communis 431  
Cucsa.252430.4 PAC:16971945 Cucumis sativus 351  
Cucsa.252430.2 A0A0A0L5E4 PAC:16971943 Cucumis sativus 499  
Cucsa.252430.3 PAC:16971944 Cucumis sativus 494  
Cucsa.252430.1 A0A0A0L5E4 PAC:16971942 Cucumis sativus 499  
Cucsa.281850.1 A0A0A0LXI8 PAC:16974365 Cucumis sativus 437  
orange1.1g010850m A0A067G5L8 PAC:18105901 Citrus sinensis 499  
orange1.1g016879m A0A067GHQ9 PAC:18105903 Citrus sinensis 381  
orange1.1g016886m A0A067GHQ9 PAC:18105902 Citrus sinensis 381  
orange1.1g018397m A0A067G5M2 PAC:18105906 Citrus sinensis 356  
orange1.1g019635m A0A067G8E5 PAC:18105907 Citrus sinensis 338  
orange1.1g020300m A0A067GHR2 PAC:18105908 Citrus sinensis 328  
orange1.1g021052m A0A067GHI0 PAC:18105910 Citrus sinensis 318  
orange1.1g018058m A0A067G5K3 PAC:18105905 Citrus sinensis 361  
orange1.1g017802m A0A067GHH7 PAC:18105904 Citrus sinensis 365  
orange1.1g048621m A0A067G0Q1 PAC:18109746 Citrus sinensis 456  
AT3G10700.1 Q8VYG2 PAC:19658912 Arabidopsis thaliana 424  
AT3G06580.1 Q9SEE5 PAC:19665123 Arabidopsis thaliana 496  
Thhalv10020814m V4NQS6 PAC:20183515 Eutrema salsugineum 418  
Thhalv10020583m V4MAA5 PAC:20181534 Eutrema salsugineum 496  
Ciclev10008332m V4UJV3 PAC:20792646 Citrus clementina 437  
Ciclev10004814m V4S2P1 PAC:20792154 Citrus clementina 499  
Ciclev10004815m V4TZZ0 PAC:20789865 Citrus clementina 499  
Ciclev10005238m V4RGF7 PAC:20792156 Citrus clementina 361  
Ciclev10005456m V4U181 PAC:20792157 Citrus clementina 318  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3062381
            1438294