Protein Domain : IPR005734

Type:  Family Name:  DNA topoisomerase VI, subunit B
Description:  DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single- or double-strand breaks, crossing the strands through one another, then resealing the breaks []. These enzymes have several functions: to remove DNA supercoils during transcription and DNA replication; for strand breakage during recombination; for chromosome condensation; and to disentangle intertwined DNA during mitosis [, ]. DNA topoisomerases are divided into two classes: type I enzymes (; topoisomerases I, III and V) break single-strand DNA, and type II enzymes (; topoisomerases II, IV and VI) break double-strand DNA [].Type II topoisomerases are ATP-dependent enzymes, and can be subdivided according to their structure and reaction mechanisms: type IIA (topoisomerase II or gyrase, and topoisomerase IV) and type IIB (topoisomerase VI). These enzymes are responsible for relaxing supercoiled DNA as well as for introducing both negative and positive supercoils [].This entry represents subunit B of topoisomerase VI, a type IIB topoisomerase found predominantly in archaea, but also in a few eukayotes, such as the plant Arabidopsis thaliana[]. This enzyme assembles as a heterotetramer, consisting of two A subunits required for DNA cleavage and two B subunits required for ATP hydrolysis. The B subunit is structurally similar to the ATPase domain of type IIA topoisomerases, but the A subunit is distinct, and instead shares homology with the Spo11 protein that mediates double-strand DNA breaks during meiotic recombination in eukaryotes []. Therefore, though related to type IIA topoisomerases, topoisomerase VI may have a distinctive mechanism of action. Short Name:  TopoVI_B
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0 Child Features

5 Contains

DB identifier Type Name
IPR003594 Domain Histidine kinase-like ATPase, C-terminal domain
IPR020568 Domain Ribosomal protein S5 domain 2-type fold
IPR010979 Domain Ribosomal protein S13-like, H2TH
IPR014721 Domain Ribosomal protein S5 domain 2-type fold, subgroup
IPR015320 Domain DNA topoisomerase VI, subunit B, transducer

4 Cross Referencess

Identifier
PTHR10871:SF4
PIRSF006553
TIGR01052
MF_00322

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003677 IPR005734
GO:0003918 IPR005734
GO:0005524 IPR005734
GO:0006265 IPR005734

4 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR005734
GO:0003918 IPR005734
GO:0005524 IPR005734
GO:0006265 IPR005734

0 Parent Features

479 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
92654 D8RF35 PAC:15419953 Selaginella moellendorffii 655  
evm.model.supercontig_84.111 PAC:16427273 Carica papaya 703  
30169.m006390 B9RI75 PAC:16821190 Ricinus communis 656  
Cucsa.153600.1 PAC:16964712 Cucumis sativus 673  
orange1.1g008575m A0A067FC40 PAC:18128784 Citrus sinensis 561  
AT3G20780.1 Q9C5V6 PAC:19663854 Arabidopsis thaliana 670  
Thhalv10020214m V4M661 PAC:20182710 Eutrema salsugineum 671  
Ciclev10014511m V4UAH1 PAC:20816960 Citrus clementina 667  
Lus10031812 PAC:23180795 Linum usitatissimum 625  
Lus10031241 PAC:23151007 Linum usitatissimum 625  
Potri.003G211000.1 U5GK39 PAC:26999562 Populus trichocarpa 673  
Gorai.013G250000.1 A0A0D2W9B0 PAC:26789730 Gossypium raimondii 669  
11853 I0Z7T5 PAC:27393427 Coccomyxa subellipsoidea C-169 641  
32362 C1MLZ8 PAC:27347553 Micromonas pusilla CCMP1545 679  
99582 C1E253 PAC:27398427 Micromonas sp RCC299 683  
49589 A4RXP1 PAC:27416629 Ostreococcus lucimarinus 672  
Thecc1EG013641t1 A0A061FWJ9 PAC:27449879 Theobroma cacao 209  
Thecc1EG040492t2 A0A061GSN0 PAC:27427563 Theobroma cacao 513  
Thecc1EG040492t1 A0A061GRN1 PAC:27427562 Theobroma cacao 669  
Migut.D00558.1.p A0A022S227 PAC:28928609 Mimulus guttatus 674  
Araha.6900s0003.1.p PAC:28851681 Arabidopsis halleri 670  
Cagra.2243s0006.1.p PAC:28919466 Capsella grandiflora 670  
Glyma.13G342900.1.p I1M541 PAC:30502900 Glycine max 673  
Brara.E02128.1.p A0A397ZBR2 PAC:30624454 Brassica rapa FPsc 675  
Bostr.19424s0572.1.p PAC:30661560 Boechera stricta 670  
Cre01.g019750.t1.1 A0A2K3E5Z0 PAC:30789216 Chlamydomonas reinhardtii 692  
Medtr2g098510.2 A0A072VDG4 PAC:31064668 Medicago truncatula 525  
Medtr2g098510.1 G7IHQ9 PAC:31064667 Medicago truncatula 671  
SapurV1A.0009s0280.1.p PAC:31446642 Salix purpurea 675  
Spipo5G0015900 PAC:31518113 Spirodela polyrhiza 672  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7770916
            11395412
            12596227
            12042765
            7980433
            10545127
            12618182