GO Term : GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity GO
Namespace:  molecular_function Obsolete:  false
description  Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
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0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

10158 Ontology Annotations

Class GO Term Gene Name Db
GOAnnotation GO:0003918 111960  
OntologyAnnotation GO:0003918 111960 GO
GOAnnotation GO:0003918 115310  
OntologyAnnotation GO:0003918 115310 GO
GOAnnotation GO:0003918 19423  
OntologyAnnotation GO:0003918 19426 GO
OntologyAnnotation GO:0003918 19423 GO
GOAnnotation GO:0003918 19426  
OntologyAnnotation GO:0003918 122380 GO
GOAnnotation GO:0003918 122380  
GOAnnotation GO:0003918 123469  
OntologyAnnotation GO:0003918 123469 GO
OntologyAnnotation GO:0003918 127267 GO
GOAnnotation GO:0003918 127267  
GOAnnotation GO:0003918 145504  
OntologyAnnotation GO:0003918 145504 GO
OntologyAnnotation GO:0003918 92654 GO
GOAnnotation GO:0003918 92654  
GOAnnotation GO:0003918 404454  
OntologyAnnotation GO:0003918 404454 GO
GOAnnotation GO:0003918 98330  
OntologyAnnotation GO:0003918 98330 GO
GOAnnotation GO:0003918 109207  
OntologyAnnotation GO:0003918 109207 GO
OntologyAnnotation GO:0003918 152781 GO
GOAnnotation GO:0003918 152781  
GOAnnotation GO:0003918 405784  
OntologyAnnotation GO:0003918 405784 GO
OntologyAnnotation GO:0003918 evm.TU.contig_37237.1 GO
GOAnnotation GO:0003918 evm.TU.contig_37237  

21 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0003677 DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0016787 hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
GO:0016887 ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
GO:0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0003676 nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0008094 DNA-dependent ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction.
GO:0016853 isomerase activity Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
GO:0016817 hydrolase activity, acting on acid anhydrides Catalysis of the hydrolysis of any acid anhydride.
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
GO:0016462 pyrophosphatase activity Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.
GO:0003916 DNA topoisomerase activity Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
GO:0042623 ATPase activity, coupled Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
GO:0017111 nucleoside-triphosphatase activity Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:1901363 heterocyclic compound binding Interacting selectively and non-covalently with heterocyclic compound.
GO:0097159 organic cyclic compound binding Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.
GO:0061505 DNA topoisomerase II activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; changes the linking number in multiples of 2.

34 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
is_a GO:0061505 GO:0003918
is_a GO:0008094 GO:0003918
part of GO:0008150 GO:0003918
has_part GO:0003677 GO:0003918
part of GO:0008152 GO:0003918
is_a GO:0003674 GO:0003918
has_part GO:0003674 GO:0003918
has_part GO:0005488 GO:0003918
has_part GO:0003676 GO:0003918
is_a GO:0016817 GO:0003918
is_a GO:0016818 GO:0003918
has_part GO:0097159 GO:0003918
is_a GO:0016853 GO:0003918
is_a GO:0042623 GO:0003918
is_a GO:0016787 GO:0003918
is_a GO:0016887 GO:0003918
is_a GO:0003824 GO:0003918
has_part GO:1901363 GO:0003918
is_a GO:0016462 GO:0003918
is_a GO:0003916 GO:0003918
is_a GO:0017111 GO:0003918
negatively regulates GO:0003918 GO:0008657
regulates GO:0003918 GO:0008657
regulates GO:0003918 GO:0072586
positively regulates GO:0003918 GO:0072587
regulates GO:0003918 GO:0072587
regulates GO:0003918 GO:2000371
regulates GO:0003918 GO:2000371
negatively regulates GO:0003918 GO:2000372
negatively regulates GO:0003918 GO:2000372

11 Synonyms

Name Type
deoxyribonucleate topoisomerase synonym
topoisomerase synonym
DNA gyrase activity synonym
deoxyribonucleic topoisomerase activity synonym
DNA topoisomerase II synonym
DNA topoisomerase (ATP-hydrolysing) synonym
DNA topoisomerase type II activity synonym
DNA topoisomerase IV activity synonym
DNA-gyrase activity synonym
type II DNA topoisomerase activity synonym
topoisomerase II synonym