GO Term : GO:0072587 DNA topoisomerase (ATP-hydrolyzing) activator activity GO
Namespace:  molecular_function Obsolete:  false
description  Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
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0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

44 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016787 hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
GO:0005515 protein binding Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
GO:0016887 ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
GO:0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0008094 DNA-dependent ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction.
GO:0016853 isomerase activity Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
GO:0016817 hydrolase activity, acting on acid anhydrides Catalysis of the hydrolysis of any acid anhydride.
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.
GO:0030234 enzyme regulator activity Binds to and modulates the activity of an enzyme.
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
GO:0016462 pyrophosphatase activity Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.
GO:0003916 DNA topoisomerase activity Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
GO:0001671 ATPase activator activity Binds to and increases the ATP hydrolysis activity of an ATPase.
GO:0043085 positive regulation of catalytic activity Any process that activates or increases the activity of an enzyme.
GO:0042623 ATPase activity, coupled Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
GO:0050790 regulation of catalytic activity Any process that modulates the activity of an enzyme.
GO:0017111 nucleoside-triphosphatase activity Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.
GO:0008047 enzyme activator activity Binds to and increases the activity of an enzyme.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0019222 regulation of metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0065009 regulation of molecular function Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:0048518 positive regulation of biological process Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0044093 positive regulation of molecular function Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:0009893 positive regulation of metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0060590 ATPase regulator activity Modulates the rate of ATP hydrolysis by an ATPase.

62 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
part of GO:2000373 GO:0072587
is_a GO:0072586 GO:0072587
is_a GO:0001671 GO:0072587
positively regulates GO:0003918 GO:0072587
part of GO:0032781 GO:0072587
part of GO:2000371 GO:0072587
positively regulates GO:0003916 GO:0072587
part of GO:0051345 GO:0072587
regulates GO:0008094 GO:0072587
positively regulates GO:0008094 GO:0072587
part of GO:0010912 GO:0072587
regulates GO:0016887 GO:0072587
part of GO:0010911 GO:0072587
regulates GO:0003916 GO:0072587
part of GO:0009893 GO:0072587
regulates GO:0003918 GO:0072587
positively regulates GO:0016787 GO:0072587
is_a GO:0003674 GO:0072587
part of GO:0048518 GO:0072587
positively regulates GO:0017111 GO:0072587
regulates GO:0003674 GO:0072587
is_a GO:0008047 GO:0072587
positively regulates GO:0016462 GO:0072587
part of GO:0043462 GO:0072587
part of GO:0050789 GO:0072587
regulates GO:0016817 GO:0072587
positively regulates GO:0003674 GO:0072587
regulates GO:0016818 GO:0072587
positively regulates GO:0016817 GO:0072587
regulates GO:0016853 GO:0072587

0 Synonyms