Protein Domain : IPR011557

Type:  Family Name:  DNA gyrase, subunit B
Description:  DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single- or double-strand breaks, crossing the strands through one another, then resealing the breaks []. These enzymes have several functions: to remove DNA supercoils during transcription and DNA replication; for strand breakage during recombination; for chromosome condensation; and to disentangle intertwined DNA during mitosis [, ]. DNA topoisomerases are divided into two classes: type I enzymes (; topoisomerases I, III and V) break single-strand DNA, and type II enzymes (; topoisomerases II, IV and VI) break double-strand DNA [].Type II topoisomerases are ATP-dependent enzymes, and can be subdivided according to their structure and reaction mechanisms: type IIA (topoisomerase II or gyrase, and topoisomerase IV) and type IIB (topoisomerase VI). These enzymes are responsible for relaxing supercoiled DNA as well as for introducing both negative and positive supercoils [].Topoisomerase II (called gyrase in bacteria) primarily introduces negative supercoils into DNA. In bacteria, topoisomerase II consists of two polypeptide subunits, gyrA and gyrB, which form a heterotetramer: (BA)2. In most eukaryotes, topoisomerase II consists of a single polypeptide, where the N- and C-terminal regions correspond to gyrB and gyrA, respectively.This entry represents the B subunit (gyrB) as found predominantly in bacteria, but does not include the topoisomerase II enzymes composed of a single polypeptide, as are found in most eukaryotes. GyrB has two functional domains: an N-terminal ATPase and a C-terminal responsible for subunit interactions, the latter differing between subunit B and single polypeptide topoisomerase II []. Short Name:  GyrB
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0 Child Features

8 Contains

DB identifier Type Name
IPR003594 Domain Histidine kinase-like ATPase, C-terminal domain
IPR020568 Domain Ribosomal protein S5 domain 2-type fold
IPR006171 Domain Toprim domain
IPR013760 Domain DNA topoisomerase, type IIA-like domain
IPR013506 Domain DNA topoisomerase, type IIA, subunit B, domain 2
IPR013759 Domain DNA topoisomerase, type IIA, central domain
IPR002288 Domain DNA gyrase B subunit, C-terminal
IPR018522 Conserved_site DNA topoisomerase, type IIA, conserved site

2 Cross Referencess

Identifier
TIGR01059
MF_01898

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0003677 IPR011557
GO:0003918 IPR011557
GO:0005524 IPR011557
GO:0006265 IPR011557
GO:0005694 IPR011557

5 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR011557
GO:0003918 IPR011557
GO:0005524 IPR011557
GO:0006265 IPR011557
GO:0005694 IPR011557

1 Parent Features

DB identifier Type Name
IPR000565 Family DNA topoisomerase, type IIA, subunit B

351 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
405784 D8QZP6 PAC:15415567 Selaginella moellendorffii 723  
29733.m000744 B9S845 PAC:16807078 Ricinus communis 732  
orange1.1g005028m A0A067DPK4 PAC:18104494 Citrus sinensis 718  
orange1.1g005193m A0A067DPY8 PAC:18104495 Citrus sinensis 709  
orange1.1g007002m A0A067DTL6 PAC:18104497 Citrus sinensis 622  
AT5G04130.1 Q94BZ7 PAC:19665371 Arabidopsis thaliana 732  
Thhalv10020150m V4NR06 PAC:20183803 Eutrema salsugineum 729  
Thhalv10012781m V4LD38 PAC:20203449 Eutrema salsugineum 735  
Ciclev10004555m V4RJR6 PAC:20790984 Citrus clementina 622  
Ciclev10004438m V4U544 PAC:20790983 Citrus clementina 718  
Lus10012114 PAC:23154955 Linum usitatissimum 749  
Lus10010428 PAC:23154081 Linum usitatissimum 660  
Potri.016G036200.1 PAC:27013480 Populus trichocarpa 731  
Potri.006G039400.1 A0A2K1ZWF4 PAC:27005271 Populus trichocarpa 721  
Gorai.003G086700.2 A0A0D2ML78 PAC:26798690 Gossypium raimondii 721  
Gorai.003G086700.1 A0A0D2QQD7 PAC:26798689 Gossypium raimondii 728  
Thecc1EG024112t1 A0A061EVM3 PAC:27421619 Theobroma cacao 726  
Migut.J01650.1.p A0A022PQM3 PAC:28941440 Mimulus guttatus 739  
Araha.1295s0002.1.p PAC:28859422 Arabidopsis halleri 738  
Araha.11756s0270.1.p PAC:28856459 Arabidopsis halleri 803  
Araha.30177s0005.2.p PAC:28843919 Arabidopsis halleri 727  
Araha.30177s0005.1.p PAC:28843918 Arabidopsis halleri 729  
Cagra.0834s0056.1.p PAC:28903786 Capsella grandiflora 728  
Cagra.0878s0008.1.p PAC:28911205 Capsella grandiflora 723  
Glyma.03G127300.1.p I1JN48 PAC:30516155 Glycine max 726  
Glyma.19G130000.1.p I1N8R8 PAC:30514412 Glycine max 724  
Brara.B00131.1.p A0A398A680 PAC:30611041 Brassica rapa FPsc 736  
Brara.E03027.1.p A0A397ZEK7 PAC:30627089 Brassica rapa FPsc 731  
Bostr.2128s0033.1.p PAC:30659209 Boechera stricta 734  
Bostr.22252s0036.1.p PAC:30659766 Boechera stricta 728  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7770916
            11395412
            12596227
            12042765
            7980433
            8982450