Protein Domain : IPR013760

Type:  Domain Name:  DNA topoisomerase, type IIA-like domain
Description:  Type IIA topoisomerases together manage chromosome integrity and topology in cells. Topoisomerase II (called gyrase in bacteria) primarily introduces negative supercoils into DNA. In bacteria, topoisomerase II consists of two polypeptide subunits, gyrA and gyrB, which form a heterotetramer: (BA)2. In most eukaryotes, topoisomerase II consists of a single polypeptide, where the N- and C-terminal regions correspond to gyrB and gyrA, respectively; this topoisomerase II forms a homodimer that is equivalent to the bacterial heterotetramer. There are four functional domains in topoisomerase II: domain 1 (N-terminal of gyrB) is an ATPase, domain 2 (C-terminal of gyrB) is responsible for subunit interactions (differs between eukaryotic and bacterial enzymes), domain 3 (N-terminal of gyrA) is responsible for the breaking-rejoining function through its capacity to form protein-DNA bridges, and domain 4 (C-terminal of gyrA) is able to non-specifically bind DNA [].Topoisomerase IV primarily decatenates DNA and relaxes positive supercoils, which is important in bacteria, where the circular chromosome becomes catenated, or linked, during replication []. Topoisomerase IV consists of two polypeptide subunits, parE and parC, where parC is homologous to gyrA and parE is homologous to gyrB.This entry represents the C-terminal of subunit B (gyrB and parE) and the N-terminal of subunit A (gyrA and parC) of bacterial gyrase and topoisomerase IV, and the equivalent region in eukaryotic topoisomerase II composed of a single polypeptide. Short Name:  Topo_IIA-like_dom
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1 Child Features

DB identifier Type Name
IPR013759 Domain DNA topoisomerase, type IIA, central domain

7 Contains

DB identifier Type Name
IPR006171 Domain Toprim domain
IPR013757 Domain Type IIA DNA topoisomerase subunit A, alpha-helical domain
IPR002205 Domain DNA topoisomerase, type IIA, subunit A/C-terminal
IPR013759 Domain DNA topoisomerase, type IIA, central domain
IPR002288 Domain DNA gyrase B subunit, C-terminal
IPR013758 Domain DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
IPR018522 Conserved_site DNA topoisomerase, type IIA, conserved site

1 Cross References

Identifier
SSF56719

9 Found Ins

DB identifier Type Name
IPR005743 Family DNA gyrase, subunit A
IPR001241 Family DNA topoisomerase, type IIA
IPR001154 Family DNA topoisomerase II, eukaryotic-type
IPR011557 Family DNA gyrase, subunit B
IPR000565 Family DNA topoisomerase, type IIA, subunit B
IPR005737 Family DNA topoisomerase IV, subunit B, Gram-negative
IPR005740 Family DNA topoisomerase 4 subunit B, Gram-positive
IPR005741 Family DNA topoisomerase IV subunit A, Gram-positive
IPR005742 Family DNA topoisomerase IV, subunit A, Gram-negative

2 GO Annotations

GO Term Gene Name
GO:0003918 IPR013760
GO:0005524 IPR013760

2 Ontology Annotations

GO Term Gene Name
GO:0003918 IPR013760
GO:0005524 IPR013760

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
98330 D8RNR7 PAC:15412854 Selaginella moellendorffii 1151  
405784 D8QZP6 PAC:15415567 Selaginella moellendorffii 723  
111960 D8S9B4 PAC:15414352 Selaginella moellendorffii 880  
127267 D8SXJ0 PAC:15411383 Selaginella moellendorffii 1151  
evm.TU.contig_37237.1 PAC:16431005 Carica papaya 43  
evm.model.supercontig_1221.1 PAC:16407101 Carica papaya 144  
evm.model.supercontig_125.26 PAC:16407255 Carica papaya 576  
evm.model.supercontig_148.20 PAC:16409239 Carica papaya 167  
evm.model.supercontig_5.163 PAC:16421266 Carica papaya 416  
evm.model.supercontig_54.41 PAC:16422393 Carica papaya 223  
evm.model.supercontig_54.40 PAC:16422392 Carica papaya 376  
evm.model.supercontig_54.38 PAC:16422389 Carica papaya 96  
29733.m000744 B9S845 PAC:16807078 Ricinus communis 732  
29743.m000297 B9SK06 PAC:16807685 Ricinus communis 540  
29864.m001478 B9RVN3 PAC:16811789 Ricinus communis 1212  
32465.m000025 B9TGB2 PAC:16825437 Ricinus communis 142  
34987.m000049 B9TCK4 PAC:16826440 Ricinus communis 83  
Cucsa.005100.10 PAC:16951072 Cucumis sativus 923  
Cucsa.005100.17 PAC:16951079 Cucumis sativus 892  
Cucsa.005100.1 PAC:16951071 Cucumis sativus 928  
Cucsa.005100.18 PAC:16951080 Cucumis sativus 751  
Cucsa.097400.1 A0A0A0KT19 PAC:16958182 Cucumis sativus 141  
Cucsa.249000.2 PAC:16971531 Cucumis sativus 1303  
Cucsa.249000.3 PAC:16971532 Cucumis sativus 1239  
Cucsa.249000.1 PAC:16971530 Cucumis sativus 1499  
orange1.1g002290m PAC:18105283 Citrus sinensis 941  
orange1.1g005028m A0A067DPK4 PAC:18104494 Citrus sinensis 718  
orange1.1g007003m A0A067DPZ0 PAC:18104496 Citrus sinensis 622  
orange1.1g005193m A0A067DPY8 PAC:18104495 Citrus sinensis 709  
orange1.1g007002m A0A067DTL6 PAC:18104497 Citrus sinensis 622  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16023670
            8982450