Protein Domain : IPR005737

Type:  Family Name:  DNA topoisomerase IV, subunit B, Gram-negative
Description:  DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single- or double-strand breaks, crossing the strands through one another, then resealing the breaks []. These enzymes have several functions: to remove DNA supercoils during transcription and DNA replication; for strand breakage during recombination; for chromosome condensation; and to disentangle intertwined DNA during mitosis [, ]. DNA topoisomerases are divided into two classes: type I enzymes (; topoisomerases I, III and V) break single-strand DNA, and type II enzymes (; topoisomerases II, IV and VI) break double-strand DNA [].Type II topoisomerases are ATP-dependent enzymes, and can be subdivided according to their structure and reaction mechanisms: type IIA (topoisomerase II or gyrase, and topoisomerase IV) and type IIB (topoisomerase VI). These enzymes are responsible for relaxing supercoiled DNA as well as for introducing both negative and positive supercoils [].This entry represents subunit B (parE) of topoisomerase IV from Gram negative bacteria. Topoisomerase IV primarily decatenates DNA and relaxes positive supercoils, which is important in bacteria, where the circular chromosome becomes catenated, or linked, during replication []. Topoisomerase IV consists of two polypeptide subunits, parC (subunit A), which is homologous to gyrA of topoisomerase II, and parE (subunit B), which is homologous to gyrB of topoisomerase II. Short Name:  TopoIV_B_Gneg
Paste the following link

0 Child Features

7 Contains

DB identifier Type Name
IPR003594 Domain Histidine kinase-like ATPase, C-terminal domain
IPR020568 Domain Ribosomal protein S5 domain 2-type fold
IPR013760 Domain DNA topoisomerase, type IIA-like domain
IPR013506 Domain DNA topoisomerase, type IIA, subunit B, domain 2
IPR013759 Domain DNA topoisomerase, type IIA, central domain
IPR002288 Domain DNA gyrase B subunit, C-terminal
IPR018522 Conserved_site DNA topoisomerase, type IIA, conserved site

3 Cross Referencess

Identifier
PR01098
TIGR01055
MF_00938

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0003677 IPR005737
GO:0003918 IPR005737
GO:0005524 IPR005737
GO:0006265 IPR005737
GO:0005694 IPR005737

5 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR005737
GO:0003918 IPR005737
GO:0005524 IPR005737
GO:0006265 IPR005737
GO:0005694 IPR005737

1 Parent Features

DB identifier Type Name
IPR001241 Family DNA topoisomerase, type IIA

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1006695m.p PAC:33619212 Brachypodium distachyon Pangenome 631  
Brdisv1pangenome1007599m.p PAC:33659565 Brachypodium distachyon Pangenome 662  
Brdisv1BdTR11A1040180m.p PAC:35696863 Brachypodium distachyon BdTR11a 935  
Brdisv1BdTR11A1041497m.p PAC:35689424 Brachypodium distachyon BdTR11a 631  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7770916
            11395412
            12596227
            12042765
            7980433
            16023670