Protein Domain : IPR018522

Type:  Conserved_site Name:  DNA topoisomerase, type IIA, conserved site
Description:  DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single- or double-strand breaks, crossing the strands through one another, then resealing the breaks []. These enzymes have several functions: to remove DNA supercoils during transcription and DNA replication; for strand breakage during recombination; for chromosome condensation; and to disentangle intertwined DNA during mitosis [, ]. DNA topoisomerases are divided into two classes: type I enzymes (; topoisomerases I, III and V) break single-strand DNA, and type II enzymes (; topoisomerases II, IV and VI) break double-strand DNA [].Type II topoisomerases are ATP-dependent enzymes, and can be subdivided according to their structure and reaction mechanisms: type IIA (topoisomerase II or gyrase, and topoisomerase IV) and type IIB (topoisomerase VI). These enzymes are responsible for relaxing supercoiled DNA as well as for introducing both negative and positive supercoils [].DNA topoisomerase II () [, , ] is one of the two types of enzyme that catalyze the interconversion of topological DNA isomers. Type II topoisomerases are ATP-dependent and act by passing a DNA segment through a transient double-strand break. Topoisomerase II is found in phages, archaebacteria, prokaryotes, eukaryotes, and in African Swine Fever virus (ASF). Bacteriophage T4 topoisomerase II consists of three subunits (the product of genes 39, 52 and 60). In prokaryotes and in archaebacteria the enzyme, known as DNA gyrase, consists of two subunits (genes GyrA and GyrB). In some bacteria, a second type II topoisomerase has been identified; it is known as topoisomerase IV and is required for chromosome segregation, it also consists of two subunits (genes parC and parE). In eukaryotes, type II topoisomerase is a homodimer. There are many regions of sequence homology between the different subtypes of topoisomerase II. The signature pattern used in this entry is a highly conserved pentapeptide, which is located in GyrB, in ParE, and in protein 39 of phage T4 topoisomerase. Short Name:  TopoIIA_CS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00177

9 Found Ins

DB identifier Type Name
IPR006171 Domain Toprim domain
IPR013760 Domain DNA topoisomerase, type IIA-like domain
IPR001241 Family DNA topoisomerase, type IIA
IPR001154 Family DNA topoisomerase II, eukaryotic-type
IPR013759 Domain DNA topoisomerase, type IIA, central domain
IPR011557 Family DNA gyrase, subunit B
IPR000565 Family DNA topoisomerase, type IIA, subunit B
IPR005737 Family DNA topoisomerase IV, subunit B, Gram-negative
IPR005740 Family DNA topoisomerase 4 subunit B, Gram-positive

4 GO Annotations

GO Term Gene Name
GO:0003677 IPR018522
GO:0003918 IPR018522
GO:0005524 IPR018522
GO:0006265 IPR018522

4 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR018522
GO:0003918 IPR018522
GO:0005524 IPR018522
GO:0006265 IPR018522

0 Parent Features

0 Proteins

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7770916
            11395412
            12596227
            12042765
            7980433
            2560656
            7773745