Protein Domain : IPR001154

Type:  Family Name:  DNA topoisomerase II, eukaryotic-type
Description:  DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single- or double-strand breaks, crossing the strands through one another, then resealing the breaks []. These enzymes have several functions: to remove DNA supercoils during transcription and DNA replication; for strand breakage during recombination; for chromosome condensation; and to disentangle intertwined DNA during mitosis [, ]. DNA topoisomerases are divided into two classes: type I enzymes (; topoisomerases I, III and V) break single-strand DNA, and type II enzymes (; topoisomerases II, IV and VI) break double-strand DNA [].Type II topoisomerases are ATP-dependent enzymes, and can be subdivided according to their structure and reaction mechanisms: type IIA (topoisomerase II or gyrase, and topoisomerase IV) and type IIB (topoisomerase VI). These enzymes are responsible for relaxing supercoiled DNA as well as for introducing both negative and positive supercoils [].This entry represents DNA topoisomerase II enzymes from eukaryotes and viruses. Topoisomerase II primarily functions in introducing negative supercoils into DNA, and is of particular importance during the segregation of chromosomes during mitosis [, ]. In eukaryotes and viruses, this enzyme occurs as a single polypeptide, with the N-terminal portion (homologous to subunit B of bacterial topoisomerase II, or gyraseB) responsible for ATPase activity and the C-terminal portion (homologous to subunit A of bacterial topoisomerase II, or gyraseA) responsible for the breaking-rejoining function through its capacity to form protein-DNA bridges. In mammals, there are at least two isozymes of this enzyme, topoisomerases II-alpha and II-beta, which are similar in structure and catalytic properties [, ]. The alpha isoform is involved in chromosome condensation and segregation. Short Name:  TopoII_euk
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2 Child Features

DB identifier Type Name
IPR028466 Family DNA topoisomerase II-alpha
IPR028467 Family DNA topoisomerase II-beta

5 Contains

DB identifier Type Name
IPR013760 Domain DNA topoisomerase, type IIA-like domain
IPR002205 Domain DNA topoisomerase, type IIA, subunit A/C-terminal
IPR013759 Domain DNA topoisomerase, type IIA, central domain
IPR013758 Domain DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
IPR018522 Conserved_site DNA topoisomerase, type IIA, conserved site

1 Cross References

Identifier
PR01158

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003677 IPR001154
GO:0003918 IPR001154
GO:0005524 IPR001154
GO:0006265 IPR001154

4 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR001154
GO:0003918 IPR001154
GO:0005524 IPR001154
GO:0006265 IPR001154

1 Parent Features

DB identifier Type Name
IPR001241 Family DNA topoisomerase, type IIA

511 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
98330 D8RNR7 PAC:15412854 Selaginella moellendorffii 1151  
127267 D8SXJ0 PAC:15411383 Selaginella moellendorffii 1151  
evm.model.supercontig_125.26 PAC:16407255 Carica papaya 576  
29864.m001478 B9RVN3 PAC:16811789 Ricinus communis 1212  
Cucsa.249000.2 PAC:16971531 Cucumis sativus 1303  
Cucsa.249000.3 PAC:16971532 Cucumis sativus 1239  
Cucsa.249000.1 PAC:16971530 Cucumis sativus 1499  
orange1.1g000459m PAC:18101881 Citrus sinensis 1484  
AT3G23890.1 P30182 PAC:19661529 Arabidopsis thaliana 1473  
AT3G23890.2 B3H4G2 PAC:19661530 Arabidopsis thaliana 1438  
Thhalv10024219m V4MN84 PAC:20193540 Eutrema salsugineum 1427  
Ciclev10030506m V4SWN8 PAC:20803645 Citrus clementina 1455  
Ciclev10030505m V4VI75 PAC:20803644 Citrus clementina 1456  
Lus10016397 PAC:23161874 Linum usitatissimum 1447  
Lus10019720 PAC:23139293 Linum usitatissimum 1461  
Potri.009G058900.3 PAC:26986246 Populus trichocarpa 1480  
Potri.009G058900.1 A0A2K1Z3I4 PAC:26986244 Populus trichocarpa 1483  
Potri.009G058900.2 B9HNR6 PAC:26986245 Populus trichocarpa 1482  
Potri.001G264000.2 A0A2K2C427 PAC:27042104 Populus trichocarpa 1464  
Potri.001G264000.1 A0A2K2C423 PAC:27042103 Populus trichocarpa 1465  
Potri.001G264000.3 A0A2K2C422 PAC:27042105 Populus trichocarpa 1249  
Gorai.011G261600.1 A0A0D2VRZ2 PAC:26812556 Gossypium raimondii 1462  
Gorai.011G261600.2 A0A0D2UY74 PAC:26812557 Gossypium raimondii 1461  
36592 I0YZH1 PAC:27387000 Coccomyxa subellipsoidea C-169 1189  
46870 C1MN24 PAC:27347410 Micromonas pusilla CCMP1545 1473  
58377 C1E5N4 PAC:27395386 Micromonas sp RCC299 1459  
41836 A4S645 PAC:27418885 Ostreococcus lucimarinus 1292  
Thecc1EG042757t1 A0A061FNA1 PAC:27443658 Theobroma cacao 1473  
Thecc1EG042757t3 A0A061FTU6 PAC:27443660 Theobroma cacao 1244  
Thecc1EG042757t2 A0A061FML4 PAC:27443659 Theobroma cacao 1285  

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7770916
            11395412
            12596227
            12042765
            7980433
            8538787
            15289664
            9631649
            14996935