Protein Domain : IPR028466

Type:  Family Name:  DNA topoisomerase II-alpha
Description:  DNA topoisomerase II makes double-strand breaks and is essential during mitosis and meiosis for proper segregation of daughter chromosomes []. Mammalian cells encode two type II isozymes, topoisomerase IIalpha (TOP2a) and beta (TOP2b), that have highly identical N-terminal ATPase and central core domains. However, they differ in their C-termini as well as expression patterns and cannot compensate for each other [].This entry represents TOP2a, which is associated with replication forks and remains tightly bound to chromosomes during mitosis. It is essential for the survival of proliferating cells and may functions in DNA replication and chromosome segregation []. Short Name:  Top2a
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10169:SF33

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0000287 IPR028466
GO:0003918 IPR028466
GO:0008301 IPR028466
GO:0006265 IPR028466
GO:0005634 IPR028466

5 Ontology Annotations

GO Term Gene Name
GO:0000287 IPR028466
GO:0003918 IPR028466
GO:0008301 IPR028466
GO:0006265 IPR028466
GO:0005634 IPR028466

1 Parent Features

DB identifier Type Name
IPR001154 Family DNA topoisomerase II, eukaryotic-type

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1331984
            15456904
            19042970