Protein Domain : IPR005743

Type:  Family Name:  DNA gyrase, subunit A
Description:  DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single- or double-strand breaks, crossing the strands through one another, then resealing the breaks []. These enzymes have several functions: to remove DNA supercoils during transcription and DNA replication; for strand breakage during recombination; for chromosome condensation; and to disentangle intertwined DNA during mitosis [, ]. DNA topoisomerases are divided into two classes: type I enzymes (; topoisomerases I, III and V) break single-strand DNA, and type II enzymes (; topoisomerases II, IV and VI) break double-strand DNA [].Type II topoisomerases are ATP-dependent enzymes, and can be subdivided according to their structure and reaction mechanisms: type IIA (topoisomerase II or gyrase, and topoisomerase IV) and type IIB (topoisomerase VI). These enzymes are responsible for relaxing supercoiled DNA as well as for introducing both negative and positive supercoils [].Topoisomerase II (called gyrase in bacteria) primarily introduces negative supercoils into DNA. In bacteria, topoisomerase II consists of two polypeptide subunits, gyrA and gyrB, which form a heterotetramer: (BA)2. In most eukaryotes, topoisomerase II consists of a single polypeptide, where the N- and C-terminal regions correspond to gyrB and gyrA, respectively.This entry represents the A subunit (gyrA) as found predominantly in bacteria, but does not include the topoisomerase II enzymes composed of a single polypeptide, as are found in most eukaryotes. GyrA has two functional domains: an N-terminal that forms the covalent DNA-protein bridge that is responsible for the breaking- and rejoining function, and a C-terminal that can bind DNA non-specifically []. Short Name:  GyrA
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0 Child Features

4 Contains

DB identifier Type Name
IPR013757 Domain Type IIA DNA topoisomerase subunit A, alpha-helical domain
IPR013760 Domain DNA topoisomerase, type IIA-like domain
IPR002205 Domain DNA topoisomerase, type IIA, subunit A/C-terminal
IPR013758 Domain DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta

2 Cross Referencess

Identifier
TIGR01063
MF_01897

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0003677 IPR005743
GO:0003918 IPR005743
GO:0005524 IPR005743
GO:0006265 IPR005743
GO:0005694 IPR005743

5 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR005743
GO:0003918 IPR005743
GO:0005524 IPR005743
GO:0006265 IPR005743
GO:0005694 IPR005743

0 Parent Features

407 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
111960 D8S9B4 PAC:15414352 Selaginella moellendorffii 880  
Cucsa.005100.10 PAC:16951072 Cucumis sativus 923  
Cucsa.005100.17 PAC:16951079 Cucumis sativus 892  
Cucsa.005100.1 PAC:16951071 Cucumis sativus 928  
orange1.1g002290m PAC:18105283 Citrus sinensis 941  
AT3G10690.1 Q9CAF6 PAC:19659696 Arabidopsis thaliana 950  
Thhalv10020005m V4M2D0 PAC:20182049 Eutrema salsugineum 937  
Lus10028879 PAC:23177257 Linum usitatissimum 940  
Potri.010G247000.3 PAC:26979942 Populus trichocarpa 886  
Potri.010G247000.2 A0A2K1YZS0 PAC:26979941 Populus trichocarpa 947  
Potri.010G247000.1 B9HVG1 PAC:26979940 Populus trichocarpa 948  
Gorai.012G020500.1 A0A0D2RWE6 PAC:26825688 Gossypium raimondii 931  
18563 I0YQD9 PAC:27394869 Coccomyxa subellipsoidea C-169 857  
88167 C1EGN9 PAC:27403934 Micromonas sp RCC299 963  
Thecc1EG044582t1 A0A061FQV0 PAC:27441345 Theobroma cacao 1368  
Migut.B01161.1.p PAC:28946767 Mimulus guttatus 953  
Araha.11756s0389.1.p PAC:28856504 Arabidopsis halleri 829  
Glyma.09G120200.1.p A0A368UHN9 PAC:30483346 Glycine max 935  
Brara.C03335.1.p A0A398A1V6 PAC:30616691 Brassica rapa FPsc 939  
Bostr.19424s0992.1.p PAC:30661392 Boechera stricta 949  
Medtr1g031690.1 G7I9Z9 PAC:31097683 Medicago truncatula 938  
SapurV1A.0036s0810.4.p PAC:31412918 Salix purpurea 953  
SapurV1A.0036s0810.3.p PAC:31412917 Salix purpurea 954  
SapurV1A.0036s0810.2.p PAC:31412916 Salix purpurea 961  
SapurV1A.0036s0810.1.p PAC:31412915 Salix purpurea 962  
Spipo3G0016600 PAC:31513263 Spirodela polyrhiza 837  
evm_27.model.AmTr_v1.0_scaffold00119.113 W1NNI3 PAC:31559513 Amborella trichopoda 963  
Traes_5AL_DA7865AEF.1 PAC:32020532 Triticum aestivum 788  
Traes_5DL_799647EA7.1 PAC:31829113 Triticum aestivum 791  
Eucgr.J00313.1.p A0A059A928 PAC:32032673 Eucalyptus grandis 953  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7770916
            11395412
            12596227
            12042765
            7980433
            8982450