Protein Domain : IPR016162

Type:  Domain Name:  Aldehyde dehydrogenase N-terminal domain
Description:  This entry represents a structural domain found at the N-terminal of aldehyde dehydrogenases []. These proteins contain two similar domains, each with a 3-layer alpha/beta/alpha structure, which probably arose from a duplication; this entry covers the N-terminal a/b/a domain. These enzymes binds NAD differently from other NAD(P)-dependent oxidoreductases. Aldehyde dehydrogenases (and ) are enzymes that oxidize a wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. In mammals at least four different forms of the enzyme are known []: class-1 (or Ald C) a tetrameric cytosolic enzyme, class-2 (or Ald M) a tetrameric mitochondrial enzyme, class- 3 (or Ald D) a dimeric cytosolic enzyme, and class IV a microsomal enzyme. Aldehyde dehydrogenases have also been sequenced from fungal and bacterial species. A number of enzymes are known to be evolutionary related to aldehyde dehydrogenases. A glutamic acid and a cysteine residue have been implicated in the catalytic activity of mammalian aldehyde dehydrogenase.This domain is also found in gamma-glutamyl phosphate reductases, also known as glutamate-5-semialdehyde dehydrogenases. Short Name:  Ald_DH_N
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0 Child Features

1 Contains

DB identifier Type Name
IPR016160 Conserved_site Aldehyde dehydrogenase, cysteine active site

1 Cross References

Identifier
G3DSA:3.40.605.10

24 Found Ins

DB identifier Type Name
IPR010061 Family Methylmalonate-semialdehyde dehydrogenase
IPR012394 Family Aldehyde dehydrogenase NAD(P)-dependent
IPR016161 Domain Aldehyde/histidinol dehydrogenase
IPR015590 Domain Aldehyde dehydrogenase domain
IPR010102 Family Succinate semialdehyde dehydrogenase
IPR005766 Family Delta l-pyrroline-5-carboxylate synthetase
IPR000965 Domain GPR domain
IPR012134 Family Glutamate-5-semialdehyde dehydrogenase
IPR005932 Family Putative 1-pyrroline-5-carboxylate dehydrogenase, Bacillales
IPR013357 Family Acetaldehyde dehydrogenase, acetylating
IPR017649 Family Succinylglutamate-semialdehyde dehydrogenase
IPR011264 Family Betaine aldehyde dehydrogenase
IPR005933 Domain Delta-1-pyrroline-5-carboxylate dehydrogenase 3
IPR011985 Family 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
IPR017749 Family 1-pyrroline dehydrogenase
IPR012079 Family Bifunctional aldehyde-alcohol dehydrogenase
IPR011408 Family Aldehyde dehydrogenase
IPR011407 Family 10-formyltetrahydrofolate dehydrogenase
IPR011966 Family Phenylacetic acid degradation protein PaaN
IPR011975 Family Phenylacetic acid degradation protein PaaN2
IPR012408 Family Acetaldehyde/propionaldehyde dehydrogenase, EutE/PduP-related
IPR017628 Family 2-hydroxymuconic semialdehyde dehydrogenase
IPR017656 Family Putative phosphonoacetaldehyde dehydrogenase
IPR005931 Family Delta-1-pyrroline-5-carboxylate dehydrogenase

3 GO Annotations

GO Term Gene Name
GO:0016491 IPR016162
GO:0008152 IPR016162
GO:0055114 IPR016162

3 Ontology Annotations

GO Term Gene Name
GO:0016491 IPR016162
GO:0008152 IPR016162
GO:0055114 IPR016162

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
410685 D8RFI6 PAC:15407190 Selaginella moellendorffii 771  
432180 D8TF82 PAC:15401358 Selaginella moellendorffii 107  
418100 D8S4P0 PAC:15404249 Selaginella moellendorffii 249  
420691 D8SCT6 PAC:15414642 Selaginella moellendorffii 445  
evm.TU.contig_26687.3 PAC:16429453 Carica papaya 248  
evm.TU.contig_37399.1 PAC:16431026 Carica papaya 45  
evm.TU.contig_44971.1 PAC:16432118 Carica papaya 37  
evm.TU.contig_46910.1 PAC:16432349 Carica papaya 163  
evm.model.supercontig_13.95 PAC:16407906 Carica papaya 172  
evm.model.supercontig_454.3 PAC:16420362 Carica papaya 721  
evm.model.supercontig_654.6 PAC:16424528 Carica papaya 241  
evm.model.supercontig_824.4 PAC:16427125 Carica papaya 169  
30143.m001194 B9SE11 PAC:16819514 Ricinus communis 732  
33312.m000029 B9THH4 PAC:16825775 Ricinus communis 209  
34882.m000023 B9TJQ0 PAC:16826388 Ricinus communis 203  
35482.m000020 B9THJ8 PAC:16826629 Ricinus communis 204  
35580.m000012 B9THI8 PAC:16826673 Ricinus communis 159  
37289.m000012 B9TDH4 PAC:16826999 Ricinus communis 77  
47209.m000006 B9TDC5 PAC:16827971 Ricinus communis 119  
59086.m000014 B9TK98 PAC:16829217 Ricinus communis 74  
29579.m000203 B9T122 PAC:16803081 Ricinus communis 49  
28537.m000018 PAC:16801060 Ricinus communis 196  
28470.m000444 B9SVT4 PAC:16800932 Ricinus communis 128  
27789.m000068 B9T896 PAC:16799185 Ricinus communis 147  
27519.m000109 B9SXQ4 PAC:16798580 Ricinus communis 117  
29215.m000010 B9T8Z9 PAC:16802478 Ricinus communis 119  
Cucsa.136260.1 PAC:16963076 Cucumis sativus 725  
Cucsa.136260.10 A0A0A0KBH3 PAC:16963077 Cucumis sativus 717  
Cucsa.175750.2 PAC:16966798 Cucumis sativus 614  
Cucsa.175750.1 PAC:16966797 Cucumis sativus 614  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2713359
            12795606