Protein Domain : IPR011407

Type:  Family Name:  10-formyltetrahydrofolate dehydrogenase
Description:  This group represents a 10-formyltetrahydrofolate dehydrogenase (FDH). This enzyme catalyses the reaction: 10-formyltetrahydrofolate + H2O + NADP+ = tetrahydrofolate + CO2 + NADPH + H+ As such it acts as an NADP-dependent aldehyde dehydrogenase []. It is composed of two catalytic domains (the N- and C-terminal domains), which are connected by a 100-amino acid residue linker (intermediate domain). The intermediate domain functions similarly to an acyl carrier protein by binding to 4'-phosphopantetheine []. FDH differs from other members of the aldehyde dehydrogenase family in that it binds the 2'-phosphate group of NADP via a water-mediated contact with Gln600, which may contribute to the specificity of the enzyme for NADP over NAD []. Short Name:  10_FTHF_DH
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0 Child Features

7 Contains

DB identifier Type Name
IPR015590 Domain Aldehyde dehydrogenase domain
IPR009081 Domain Acyl carrier protein-like
IPR016162 Domain Aldehyde dehydrogenase N-terminal domain
IPR005793 Domain Formyl transferase, C-terminal
IPR002376 Domain Formyl transferase, N-terminal
IPR016160 Conserved_site Aldehyde dehydrogenase, cysteine active site
IPR001555 Active_site Phosphoribosylglycinamide formyltransferase, active site

1 Cross References

Identifier
PIRSF036489

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0016155 IPR011407
GO:0006730 IPR011407
GO:0009258 IPR011407
GO:0055114 IPR011407
GO:0005737 IPR011407

5 Ontology Annotations

GO Term Gene Name
GO:0016155 IPR011407
GO:0006730 IPR011407
GO:0009258 IPR011407
GO:0055114 IPR011407
GO:0005737 IPR011407

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1848231
            17302434
            17884809