Protein Domain : IPR015590

Type:  Domain Name:  Aldehyde dehydrogenase domain
Description:  Aldehyde dehydrogenases (and ) are enzymes that oxidize a wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. In mammals at least four different forms of the enzyme are known []: class-1 (or Ald C) a tetrameric cytosolic enzyme, class-2 (or Ald M) a tetrameric mitochondrial enzyme, class- 3 (or Ald D) a dimeric cytosolic enzyme, and class IV a microsomal enzyme. Aldehyde dehydrogenases have also been sequenced from fungal and bacterial species. A number of enzymes are known to be evolutionary related to aldehyde dehydrogenases. A glutamic acid and a cysteine residue have been implicated in the catalytic activity of mammalian aldehyde dehydrogenase. These residues are conserved in all the enzymes of this entry.Some of the proteins in this entry are allergens. Allergies are hypersensitivity reactions of the immune system to specific substances called allergens (such as pollen, stings, drugs, or food) that, in most people, result in no symptoms. A nomenclature system has been established for antigens (allergens) that cause IgE-mediated atopic allergies in humans [WHO/IUIS Allergen Nomenclature SubcommitteeKing T.P., Hoffmann D., Loewenstein H., Marsh D.G., Platts-Mills T.A.E., Thomas W. Bull. World Health Organ. 72:797-806(1994)]. This nomenclature system is defined by a designation that is composed of the first three letters of the genus; a space; the first letter of thespecies name; a space and an arabic number. In the event that two species names have identical designations, they are discriminated from one anotherby adding one or more letters (as necessary) to each species designation.The allergens in this family include allergens with the following designations: Alt a 10 and Cla h 3. Short Name:  Aldehyde_DH_dom
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1 Child Features

DB identifier Type Name
IPR000965 Domain GPR domain

4 Contains

DB identifier Type Name
IPR016163 Domain Aldehyde dehydrogenase, C-terminal
IPR016162 Domain Aldehyde dehydrogenase N-terminal domain
IPR020593 Conserved_site Gamma-glutamyl phosphate reductase GPR, conserved site
IPR016160 Conserved_site Aldehyde dehydrogenase, cysteine active site

1 Cross References

Identifier
PF00171

19 Found Ins

DB identifier Type Name
IPR010061 Family Methylmalonate-semialdehyde dehydrogenase
IPR012394 Family Aldehyde dehydrogenase NAD(P)-dependent
IPR010102 Family Succinate semialdehyde dehydrogenase
IPR005932 Family Putative 1-pyrroline-5-carboxylate dehydrogenase, Bacillales
IPR013357 Family Acetaldehyde dehydrogenase, acetylating
IPR017649 Family Succinylglutamate-semialdehyde dehydrogenase
IPR011264 Family Betaine aldehyde dehydrogenase
IPR005933 Domain Delta-1-pyrroline-5-carboxylate dehydrogenase 3
IPR011985 Family 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
IPR017749 Family 1-pyrroline dehydrogenase
IPR012079 Family Bifunctional aldehyde-alcohol dehydrogenase
IPR011408 Family Aldehyde dehydrogenase
IPR011407 Family 10-formyltetrahydrofolate dehydrogenase
IPR011966 Family Phenylacetic acid degradation protein PaaN
IPR011975 Family Phenylacetic acid degradation protein PaaN2
IPR012408 Family Acetaldehyde/propionaldehyde dehydrogenase, EutE/PduP-related
IPR017628 Family 2-hydroxymuconic semialdehyde dehydrogenase
IPR017656 Family Putative phosphonoacetaldehyde dehydrogenase
IPR005931 Family Delta-1-pyrroline-5-carboxylate dehydrogenase

3 GO Annotations

GO Term Gene Name
GO:0016491 IPR015590
GO:0008152 IPR015590
GO:0055114 IPR015590

3 Ontology Annotations

GO Term Gene Name
GO:0016491 IPR015590
GO:0008152 IPR015590
GO:0055114 IPR015590

1 Parent Features

DB identifier Type Name
IPR016161 Domain Aldehyde/histidinol dehydrogenase

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
36550 D8T921 PAC:15410058 Selaginella moellendorffii 105  
410567 D8RF57 PAC:15406449 Selaginella moellendorffii 123  
410566 D8RF56 PAC:15406448 Selaginella moellendorffii 123  
410685 D8RFI6 PAC:15407190 Selaginella moellendorffii 771  
135319 D8TA14 PAC:15413417 Selaginella moellendorffii 168  
135313 D8TA29 PAC:15413409 Selaginella moellendorffii 110  
231526 D8RHL6 PAC:15417486 Selaginella moellendorffii 488  
136248 D8TBI5 PAC:15415624 Selaginella moellendorffii 141  
94547 D8RHU8 PAC:15402634 Selaginella moellendorffii 157  
431510 D8TCW6 PAC:15401317 Selaginella moellendorffii 158  
4672 D8TCZ3 PAC:15417421 Selaginella moellendorffii 223  
412043 D8RJV3 PAC:15408406 Selaginella moellendorffii 108  
412036 D8RJU6 PAC:15408379 Selaginella moellendorffii 257  
79174 D8QW82 PAC:15422133 Selaginella moellendorffii 540  
432180 D8TF82 PAC:15401358 Selaginella moellendorffii 107  
432290 D8TFJ7 PAC:15402187 Selaginella moellendorffii 204  
174224 D8RTU8 PAC:15416172 Selaginella moellendorffii 503  
232458 D8RVD8 PAC:15419730 Selaginella moellendorffii 497  
432334 D8TFP3 PAC:15402736 Selaginella moellendorffii 183  
432338 D8TFP7 PAC:15402740 Selaginella moellendorffii 122  
270375 D8QWI7 PAC:15419609 Selaginella moellendorffii 497  
80113 D8QXP9 PAC:15402934 Selaginella moellendorffii 553  
432450 D8TG16 PAC:15403507 Selaginella moellendorffii 162  
107615 D8S3N1 PAC:15422083 Selaginella moellendorffii 191  
15413 D8S3N0 PAC:15414257 Selaginella moellendorffii 193  
268124 D8S3M4 PAC:15411878 Selaginella moellendorffii 491  
233053 D8S3N4 PAC:15419569 Selaginella moellendorffii 491  
417609 D8S306 PAC:15405206 Selaginella moellendorffii 480  
443623 D8S308 PAC:15415271 Selaginella moellendorffii 494  
418531 D8S605 PAC:15407373 Selaginella moellendorffii 163  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2713359