| Type: | Conserved_site | Name: | Gamma-glutamyl phosphate reductase GPR, conserved site |
| Description: | Gamma-glutamyl phosphate reductase () (GPR) is the enzyme that catalyzes the second step in the biosynthesis of proline from glutamate, the NADP-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. In bacteria (gene proA) and yeast [] (gene PRO2), GPR is a monofunctional protein, while in plants and mammals, it is a bifunctional enzyme (P5CS) [] that consists of two domains, an N-terminal glutamate 5-kinase domain () and a C-terminal GPR domain.This signature pattern covers a conserved region that contains two histidine residues. This region is located in the last third of GPR. | Short Name: | G-glutamylP_reductase_CS |
| DB identifier | Type | Name |
|---|---|---|
| IPR016161 | Domain | Aldehyde/histidinol dehydrogenase |
| IPR015590 | Domain | Aldehyde dehydrogenase domain |
| IPR016163 | Domain | Aldehyde dehydrogenase, C-terminal |
| IPR005766 | Family | Delta l-pyrroline-5-carboxylate synthetase |
| IPR000965 | Domain | GPR domain |
| IPR012134 | Family | Glutamate-5-semialdehyde dehydrogenase |
| GO Term | Gene Name |
|---|---|
| GO:0004350 | IPR020593 |
| GO:0006561 | IPR020593 |
| GO:0055114 | IPR020593 |
