Protein Domain : IPR012134

Type:  Family Name:  Glutamate-5-semialdehyde dehydrogenase
Description:  Gamma-glutamyl phosphate reductase (GPR), also known as glutamate-5-semialdehyde dehydrogenase, catalyses the second step of proline biosynthesis, the NADPH-dependent reversible reduction of gamma-glutamyl phosphate to glutamate-5-semialdehyde as shown below. L-glutamyl 5-phosphate + NADPH + H(+) = L-glutamate 5-semialdehyde + phosphate + NADP(+)In bacteria and yeast, GPR is a monofunctional protein, while in plants and mammals, it is part of a bifunctional enzyme that consists of two domains, an N-terminal glutamate 5-kinase domain () and a C-terminal GPR domain [, , ].This entry represents the monofunctional gamma-glutamyl phosphate reductase found in bacteria and yeasts. Structural studies indicate that this protein is composed of three domains and belongs to the aldehyde dehydrogenase structural family []. The first two domains, the catalytic and cofactor binding domains respectively, both form a similar three layered alpha-beta-alpha fold, and are thought to close around the NADPH and gamma-glutamyl-phosphate ligands upon binding in order to orient a conserved cysteine residue for catalysis. The third domain is the oligomerisation domain which forms an antiparallel beta sheet. The biological oligomerisation state of the protein is not currently known, but like most members of the aldehyde dehydrogenase family it is expected to be either a dimer or a tetramer. Short Name:  Glu-5-SA_DH
Paste the following link

0 Child Features

3 Contains

DB identifier Type Name
IPR016163 Domain Aldehyde dehydrogenase, C-terminal
IPR016162 Domain Aldehyde dehydrogenase N-terminal domain
IPR020593 Conserved_site Gamma-glutamyl phosphate reductase GPR, conserved site

1 Cross References

Identifier
PIRSF000151

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004350 IPR012134
GO:0050661 IPR012134
GO:0006561 IPR012134
GO:0055114 IPR012134

4 Ontology Annotations

GO Term Gene Name
GO:0004350 IPR012134
GO:0050661 IPR012134
GO:0006561 IPR012134
GO:0055114 IPR012134

0 Parent Features

17 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
30966 C1MI40 PAC:27345469 Micromonas pusilla CCMP1545 464  
59938 C1EA40 PAC:27404583 Micromonas sp RCC299 463  
1184 A4S3Y2 PAC:27416129 Ostreococcus lucimarinus 420  
Traes_3AL_302AF461E.2 PAC:31804543 Triticum aestivum 434  
Brdisv1pangenome1009376m.p PAC:33659111 Brachypodium distachyon Pangenome 413  
Brdisv1BdTR11A1040597m.p PAC:35695418 Brachypodium distachyon BdTR11a 413  
Brdisv1BdTR11A1041560m.p PAC:35687977 Brachypodium distachyon BdTR11a 404  
Cz04g39260.t1 PAC:38236015 Chromochloris zofingiensis 438  
Zm00001d012391_P013 A0A1D6G8F7 PAC:40263267 Zea mays 407  
Zm00001d010056_P015 A0A1D6FP09 PAC:40259776 Zea mays 419  
Zm00001d010056_P014 A0A1D6FP09 PAC:40259775 Zea mays 419  
Zm00001d010056_P011 A0A1D6FP06 PAC:40259773 Zea mays 460  
Zm00001d038358_P009 A0A1D6M5P0 PAC:40224520 Zea mays 419  
Zm00001d038358_P008 A0A1D6M5P0 PAC:40224519 Zea mays 419  
Pl08G0000371300.2.v1 PAC:44391060 Phaseolus lunatus 464  
Traes_3AL_302AF461E.1 PAC:31804542 Triticum aestivum 434  
Traes_3AL_302AF461E.1 PAC:31804542 Triticum aestivum 434  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1384052
            8896266
            14705032
            11375165