3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0009013 | IPR010102 |
| GO:0009450 | IPR010102 |
| GO:0055114 | IPR010102 |
| Type: | Family | Name: | Succinate semialdehyde dehydrogenase |
| Description: | Succinate semialdehyde dehydrogenase (SSADH) is one of three enzymes constituting 4-aminobutyrate (GABA) degradation in both prokaryotes and eukaryotes, catalysing the (NAD(P)+)-dependent catabolism reaction of succinate semialdehyde to succinate for metabolism by the citric acid cycle. In Escherichia coli, SSADH is located in a unidirectionally transcribed gene cluster encoding enzymes for GABA degradation and is suggested to be co-transcribed with succinate semialdehyde transaminase from a common promoter upstream of SSADH []. Similar gene arrangements can be found in characterised Ralstonia eutropha(Alcaligenes eutrophus) [] and the genome analysis of Bacillus subtilis. Prokaryotic SSADH enzymes () share high sequence homology to characterised SSADH from rat and human (), exhibiting conservation of proposed cofactor binding residues, and putative active sites (G-237 and G-242, C-293 and G-259 respectively of rat SSADH) []. Eukaryotic SSADH enzymes exclusively utilise NAD+ as a cofactor, exhibiting little to no NADP+ activity []. While a NADP+ preference has been detected in prokaryotes in addition to both NADP+- and NAD+-dependencies as in E. coli, Pseudomonas, and Klebsiella pneumoniae[]. The function of this alternative SSADH currentlyis unknown, but has been suggested to play a possible role in 4-hydroxyphenylacetic degradation []. SSADH enzyme belongs to the aldehyde dehydrogenase family, sharing a common evolutionary origin and enzymatic mechanism with lactaldehyde dehydrogenase []. Like in lactaldehyde dehydrogenase and SSADH, the mammalian catalytic glutamic acid and cysteine residues are conserved in all the enzymes of this family. | Short Name: | Succ_semiAld_DH |
| GO Term | Gene Name |
|---|---|
| GO:0009013 | IPR010102 |
| GO:0009450 | IPR010102 |
| GO:0055114 | IPR010102 |
