Protein Domain : IPR016160

Type:  Conserved_site Name:  Aldehyde dehydrogenase, cysteine active site
Description:  Aldehyde dehydrogenases (and ) are enzymes that oxidize a wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. In mammals at least four different forms of the enzyme are known []: class-1 (or Ald C) a tetrameric cytosolic enzyme, class-2 (or Ald M) a tetrameric mitochondrial enzyme, class- 3 (or Ald D) a dimeric cytosolic enzyme, and class IV a microsomal enzyme. Aldehyde dehydrogenases have also been sequenced from fungal and bacterial species. A number of enzymes are known to be evolutionary related to aldehyde dehydrogenases. A glutamic acid and a cysteine residue have been implicated in the catalytic activity of mammalian aldehyde dehydrogenase. These residues are conserved in all the enzymes of this entry. This entry represents the cysteine active site. Short Name:  Ald_DH_CS_CYS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00070

9 Found Ins

DB identifier Type Name
IPR012394 Family Aldehyde dehydrogenase NAD(P)-dependent
IPR016161 Domain Aldehyde/histidinol dehydrogenase
IPR015590 Domain Aldehyde dehydrogenase domain
IPR016162 Domain Aldehyde dehydrogenase N-terminal domain
IPR017649 Family Succinylglutamate-semialdehyde dehydrogenase
IPR011264 Family Betaine aldehyde dehydrogenase
IPR017749 Family 1-pyrroline dehydrogenase
IPR011408 Family Aldehyde dehydrogenase
IPR011407 Family 10-formyltetrahydrofolate dehydrogenase

3 GO Annotations

GO Term Gene Name
GO:0016491 IPR016160
GO:0008152 IPR016160
GO:0055114 IPR016160

3 Ontology Annotations

GO Term Gene Name
GO:0016491 IPR016160
GO:0008152 IPR016160
GO:0055114 IPR016160

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2713359