Protein Domain : IPR011264

Type:  Family Name:  Betaine aldehyde dehydrogenase
Description:  Under osmotic stress, betaine aldehyde dehydrogenase oxidises glycine betaine aldehyde into the osmoprotectant glycine betaine, via the second of two oxidation steps from exogenously supplied choline or betaine aldehyde. This choline-glycine betaine synthesis pathway can be found in Gram-positive and Gram-negative bacteria. In Escherichia coli, betaine aldehyde dehydrogenase (betB) is osmotically co-induced with choline dehydrogenase (betA) in the presence of choline. These dehydrogenases are located in a betaine gene cluster with the upstream choline transporter (betT) and transcriptional regulator (betI) []. Similar to E. coli, betaine synthesis in Staphylococcus xylosusis also influenced by osmotic stress and the presence of choline with genes localised in a functionally equivalent gene cluster []. Organisation of the betaine gene cluster in Rhizobium meliloti(Sinorhizobium meliloti) and Bacillus subtilisdiffers from that of E. coli by the absence of upstream choline transporter and transcriptional regulator homologues [, ]. Additionally, B. subtilis co-expresses a type II alcohol dehydrogenase with betaine aldehyde dehydrogenase instead of choline dehydrogenase as in E. coli, S. xylosus, and S. meliloti []. Betaine aldehyde dehydrogenase is a member of the aldehyde dehydrogenase family. Short Name:  BADH
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0 Child Features

3 Contains

DB identifier Type Name
IPR015590 Domain Aldehyde dehydrogenase domain
IPR016162 Domain Aldehyde dehydrogenase N-terminal domain
IPR016160 Conserved_site Aldehyde dehydrogenase, cysteine active site

2 Cross Referencess

Identifier
TIGR01804
MF_00804

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0008802 IPR011264
GO:0046872 IPR011264
GO:0019285 IPR011264

3 Ontology Annotations

GO Term Gene Name
GO:0008802 IPR011264
GO:0046872 IPR011264
GO:0019285 IPR011264

0 Parent Features

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1006935m.p PAC:33658763 Brachypodium distachyon Pangenome 511  
Brdisv1pangenome1009379m.p PAC:33621939 Brachypodium distachyon Pangenome 488  
Brdisv1pangenome1008811m.p PAC:33620473 Brachypodium distachyon Pangenome 531  
Brdisv1BdTR11A1046290m.p PAC:35696258 Brachypodium distachyon BdTR11a 494  
Brdisv1BdTR11A1046247m.p PAC:35690127 Brachypodium distachyon BdTR11a 488  
Brdisv1BdTR11A1039951m.p PAC:35691994 Brachypodium distachyon BdTR11a 532  
Brdisv1BdTR11A1041736m.p PAC:35688777 Brachypodium distachyon BdTR11a 511  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3065456
            10094709
            9141699