Protein Domain : IPR012079

Type:  Family Name:  Bifunctional aldehyde-alcohol dehydrogenase
Description:  This enzyme has two NAD+-dependent activities: alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ACDH) [, , ]. It controls ethanol and acetate production under aerobic conditions []. The N-terminal region of the protein is highly homologous to aldehyde:NAD(+) oxidoreductases, whereas the C-terminal region is homologous to a family of Fe(2+)-dependent ethanol:NAD(+) oxidoreductases. In Escherichia coli, this fusion protein also functions as a pyruvate formate lyase deactivase []. Short Name:  Bifunc_Ald-ADH
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0 Child Features

4 Contains

DB identifier Type Name
IPR015590 Domain Aldehyde dehydrogenase domain
IPR016162 Domain Aldehyde dehydrogenase N-terminal domain
IPR001670 Domain Alcohol dehydrogenase, iron-type
IPR018211 Conserved_site Alcohol dehydrogenase, iron-type, conserved site

1 Cross References

Identifier
PIRSF000111

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0004022 IPR012079
GO:0008774 IPR012079
GO:0006066 IPR012079
GO:0015976 IPR012079
GO:0055114 IPR012079

5 Ontology Annotations

GO Term Gene Name
GO:0004022 IPR012079
GO:0008774 IPR012079
GO:0006066 IPR012079
GO:0015976 IPR012079
GO:0055114 IPR012079

0 Parent Features

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1BdTR12c1039934m.p PAC:34404546 Brachypodium distachyon BdTR12c 873  
Brdisv1BdTR11A1040301m.p PAC:35692456 Brachypodium distachyon BdTR11a 924  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7980441
            23201265
            18726959
            6998946
            10922373