Protein Domain : IPR001670

Type:  Domain Name:  Alcohol dehydrogenase, iron-type
Description:  Alcohol dehydrogenase () (ADH) catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. Currently three, structurally and catalytically, different types of alcohol dehydrogenases are known: Zinc-containing 'long-chain' alcohol dehydrogenases.Insect-type, or 'short-chain' alcohol dehydrogenases.Iron-containing alcohol dehydrogenases.Iron-containing ADH's have been found in yeast (gene ADH4) [], as well as in Zymomonas mobilis(gene adhB) []. These two iron-containing ADH's are closely related to the following enzymes:Escherichia colipropanediol oxidoreductase () (gene fucO) [], an enzyme involved in the metabolism of fucose and which also seems to contain ferrous ion(s).Clostridium acetobutylicumNADPH- and NADH-dependent butanol dehydrogenases () (genes adh1, bdhA and bdhB) [], an enzyme which has activity using butanol and ethanol as substrates.E. coli adhE [], an iron-dependent enzyme which harbor three different activities: alcohol dehydrogenase, acetaldehyde dehydrogenase (acetylating) () and pyruvate-formate-lyase deactivase.Bacterial glycerol dehydrogenase () (gene gldA or dhaD) [].Clostridium kluyveriNAD-dependent 4-hydroxybutyrate dehydrogenase (4hbd) ().Citrobacter freundiiand Klebsiella pneumoniae1,3-propanediol dehydrogenase () (gene dhaT).Bacillus methanolicusNAD-dependent methanol dehydrogenase () [].E. coli and Salmonella typhimuriumethanolamine utilization protein eutG.E. coli hypothetical protein yiaY. Short Name:  ADH_Fe
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0 Child Features

1 Contains

DB identifier Type Name
IPR018211 Conserved_site Alcohol dehydrogenase, iron-type, conserved site

1 Cross References

Identifier
PF00465

4 Found Ins

DB identifier Type Name
IPR016205 Family Glycerol dehydrogenase
IPR012079 Family Bifunctional aldehyde-alcohol dehydrogenase
IPR017775 Family Alcohol dehydrogenase, iron-type, phosphonate metabolism-associated
IPR013460 Family Lactaldehyde reductase

3 GO Annotations

GO Term Gene Name
GO:0016491 IPR001670
GO:0046872 IPR001670
GO:0055114 IPR001670

3 Ontology Annotations

GO Term Gene Name
GO:0016491 IPR001670
GO:0046872 IPR001670
GO:0055114 IPR001670

0 Parent Features

26 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
58857 C1MUL8 PAC:27348308 Micromonas pusilla CCMP1545 487  
81646 C1E6U2 PAC:27395617 Micromonas sp RCC299 406  
24600 A4RY11 PAC:27416851 Ostreococcus lucimarinus 413  
Cre16.g669150.t1.2 A8JB39 PAC:30777295 Chlamydomonas reinhardtii 325  
Cre16.g669125.t1.1 A0A2K3CUC5 PAC:30777046 Chlamydomonas reinhardtii 534  
Cre17.g746997.t1.1 A8JI07 PAC:30781848 Chlamydomonas reinhardtii 954  
Brdisv1pangenome1007608m.p PAC:33655762 Brachypodium distachyon Pangenome 387  
Brdisv1pangenome1008240m.p PAC:33620551 Brachypodium distachyon Pangenome 873  
Brdisv1pangenome1008558m.p PAC:33620682 Brachypodium distachyon Pangenome 382  
Brdisv1pangenome1009770m.p PAC:33640403 Brachypodium distachyon Pangenome 370  
Brdisv1pangenome1011140m.p PAC:33657071 Brachypodium distachyon Pangenome 382  
Brdisv1pangenome1010813m.p PAC:33657077 Brachypodium distachyon Pangenome 223  
Brdisv1pangenome1011388m.p PAC:33623838 Brachypodium distachyon Pangenome 210  
Brdisv1BdTR12c1039934m.p PAC:34404546 Brachypodium distachyon BdTR12c 873  
Brdisv1BdTR11A1048399m.p PAC:35693891 Brachypodium distachyon BdTR11a 484  
Brdisv1BdTR11A1048911m.p PAC:35689335 Brachypodium distachyon BdTR11a 223  
Brdisv1BdTR11A1049554m.p PAC:35694529 Brachypodium distachyon BdTR11a 253  
Brdisv1BdTR11A1044378m.p PAC:35689536 Brachypodium distachyon BdTR11a 382  
Brdisv1BdTR11A1040705m.p PAC:35687594 Brachypodium distachyon BdTR11a 370  
Brdisv1BdTR11A1040301m.p PAC:35692456 Brachypodium distachyon BdTR11a 924  
Brdisv1BdTR11A1040187m.p PAC:35694062 Brachypodium distachyon BdTR11a 387  
Brdisv1BdTR11A1041094m.p PAC:35687854 Brachypodium distachyon BdTR11a 382  
Brdisv1BdTR11A1041492m.p PAC:35696383 Brachypodium distachyon BdTR11a 385  
Vocar.0039s0035.2.p PAC:32897816 Volvox carteri 952  
Vocar.0039s0035.1.p PAC:32897815 Volvox carteri 952  
Vocar.0039s0016.1.p PAC:32897796 Volvox carteri 953  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2015910
            3584063
            2661535
            1644761
            1385386
            8132480
            2823079